Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients.

Clinical and Vaccine Immunology : CVI
Hélène Fricker-HidalgoClaudine Pinel

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a frequent complication in cystic fibrosis patients. The diagnosis remains difficult and requires a combination of clinical, radiological, biological, and mycological criteria. The aim of this study was to analyze the added value of two recombinant antigens, rAspf4 and rAspf6, associated with the detection of specific IgG; precipitins; total IgE; and Aspergillus fumigatus in sputum for the diagnosis of ABPA. In a retrospective study, we determined the specific IgE responses to these recombinants in 133 sera of 65 cystic fibrosis patients. We selected an average of five serum samples from each of the 17 patients with ABPA (13 proven and 4 probable ABPA) and from 3 patients with Aspergillus bronchitis and rhinosinusitis. One serum sample for the 45 patients without ABPA was tested. The sensitivity of specific IgE detection against rAspf4 calculated per patient (92.3%) was significantly higher (P < 0.05) than that of rAspf6 (53.8%). When rAspf4 IgE detection was associated with anti-Aspergillus IgG enzyme-linked immunosorbent assay (ELISA) and precipitin detection, the sensitivity rose to 100%. The specificities of rAspf4 and rAspf6 IgE detection were 93.7% and 91.6%, respectively....Continue Reading

References

Jun 18, 2002·Chest·Ayman O Soubani, Pranatharthi H Chandrasekar
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David A StevensUNKNOWN Participants in the Cystic Fibrosis Foundation Consensus Conference
Apr 28, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carmen CasaultaMartin H Schoeni
Jun 23, 2005·Allergy·I Tillie-Leblond, A-B Tonnel
Nov 30, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Alan P KnutsenJudy Consolino
Dec 16, 2005·Chemical Immunology and Allergy·Reto CrameriClaudio Rhyner
Apr 22, 2006·Diagnostic Microbiology and Infectious Disease·Jacqueline SarfatiJean-Paul Latgé
Jul 25, 2006·Clinical and Molecular Allergy : CMA·Viswanath P KurupNaveen K Bansal
Sep 9, 2006·American Journal of Respiratory and Critical Care Medicine·Richard KraemerReto Crameri
Nov 30, 2006·Current Opinion in Pulmonary Medicine·Christine Virnig, Robert K Bush
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Pooja TakharHannah J Gould
Apr 5, 2007·American Journal of Respiratory and Critical Care Medicine·Frank J Accurso
Aug 11, 2007·Respiratory Medicine·Edilamara de OliveiraJorge Kalil
Sep 28, 2007·The European Respiratory Journal·P LatzinC Casaulta
Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshUNKNOWN Infectious Diseases Society of America
Apr 25, 2008·Pediatric Pulmonology·Jacquelyn M Zirbes, Carlos E Milla
Mar 7, 2009·Chest·Ritesh Agarwal
Sep 1, 2006·Medical Mycology·P BowyerD W Denning

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Citations

Dec 29, 2011·Arhiv za higijenu rada i toksikologiju·Ljerka Prester
May 30, 2012·Clinics in Chest Medicine·Sonia N Bains, Marc A Judson
Mar 7, 2015·Infection·Christian GeltnerCornelia Lass-Flörl
Jul 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V N Maturu, R Agarwal
Nov 28, 2012·Journal de mycologie médicale·F Persat
May 23, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Yael GernezRichard B Moss
Nov 14, 2014·Journal of Clinical Microbiology·A OlivaS Ranque
Jun 12, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P M MatricardiM Ollert
May 2, 2012·Therapeutic Advances in Respiratory Disease·Mahboobeh Mahdavinia, Leslie C Grammer
Mar 15, 2018·Medical Mycology·Carsten SchwarzUNKNOWN ECMM/ISHAM working group Fungal respiratory infections in Cystic Fibrosis (Fri-CF)
Jun 22, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Valliappan MuthuRitesh Agarwal
May 16, 2019·Journal of Medical Microbiology·Nada S AlghamdiDaniel Peckham
May 30, 2020·International Journal of Molecular Medicine·Jia-Jie ChenKunmei Ji
Mar 20, 2018·Indian Journal of Pediatrics·Meenu SinghGyan Ranjan Nayak
Jan 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Brian C M LiBradley S Quon
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Patience EschenhagenCarsten Schwarz

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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