PMID: 2492141Feb 1, 1989Paper

Recombinant alpha-2a interferon plus vinblastine in the treatment of metastatic renal cell carcinoma

American Journal of Clinical Oncology
M R SertoliR Rosso

Abstract

Twenty consecutive metastatic renal cell carcinoma patients were treated with a combination of recombinant alpha-2a interferon (18 X 10(6) U three times weekly) and vinblastine (0.1 mg/kg every 3 weeks). Two patients (10% response rate; 95% confidence limits 1.23-31.7%) achieved partial response and 11 (55%) stable disease. Toxicity was significant but always acceptable: most frequently, patients complained of fever and flu-like symptoms (18 of 19 patients), fatigue (18 of 19 patients), worsening in performance status (15 of 19 patients), and anorexia (15 of 19). The combination of recombinant alpha-2a interferon and vinblastine is active in renal cell carcinoma.

Citations

Jan 1, 1990·Urological Research·R Heicappell, R Ackermann
Jun 1, 1994·Critical Reviews in Oncology/hematology·K Pittman, P Selby
Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marios DecatrisKen O'Byrne
Nov 1, 1996·Cancer Control : Journal of the Moffitt Cancer Center·G P Haas, G G Hillman
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PyrhönenP L Kellokumpu-Lehtinen

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