PMID: 2101480Sep 1, 1990Paper

Recombinant attenuated Vibrio cholerae strains used as live oral vaccines

Research in Microbiology
J B Kaper, M M Levine

Abstract

Although great strides have been made in the development of recombinant attenuated Vibrio cholerae vaccine strains, the task has not been as simple as once imagined. The initial vaccine candidates proved to be unexpectedly reactogenic but further derivatives, such as CVD103-HgR, are well-tolerated, immunogenic and protective after a single dose. In addition, this strain carries a selectable marker to distinguish it from wild strains and has been evaluated in a practical, lyophilized formulation (Levine et al., 1988b). While CVD103-HgR is being further evaluated in expanded trials, we are also investigating a new secretogenic factor which could possibly explain the diarrhoea seen with the earlier vaccine strains. Hopefully, these studies will achieve the long-sought goal of a safe and effective vaccine for the prevention of cholera.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T Honda, R A Finkelstein
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D M Gill, R Meren
Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M LevineJ P Libonati
Oct 1, 1988·The Journal of Experimental Medicine·D A HerringtonM M Levine
May 1, 1987·Infection and Immunity·Y IchinoseM Iwanaga

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Citations

Jan 1, 1993·Vaccine·M M Levine, J B Kaper
Jun 1, 1993·Baillière's Clinical Gastroenterology·M M Levine, F Noriega
Jan 1, 1992·Vaccine·P A Manning
Jun 21, 2005·Current Opinion in Immunology·Joaquín Sánchez, Jan Holmgren
Mar 24, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wilbur H ChenMyron M Levine
Oct 9, 2007·Comparative Immunology, Microbiology and Infectious Diseases·D BimczokH J Rothkötter
Nov 9, 2011·Nature Reviews. Gastroenterology & Hepatology·John ClemensJan Holmgren
Sep 23, 2006·Expert Review of Vaccines·Edward T RyanFirdausi Qadri
Jan 1, 1995·Parasitology·P WilladsenJ Hungerford
Apr 4, 2001·Journal of Travel Medicine·E T Ryan, S B Calderwood

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