PMID: 8591086Nov 1, 1995Paper

Recombinant BCG therapy suppresses melanoma tumor growth

Annals of Surgical Oncology
R B DudaG Abu-Jawdeh

Abstract

Melanoma is the fastest rising cancer in the United States. Bacillus Calmette-Guerin (BCG) has been genetically engineered to actively express and secrete the cytokine interleukin-2 (IL-2). Both BCG and IL-2 have known potent antitumor and immunomodulatory properties. This recombinant BCG (rBCG 3A) has been tested as an intratumoral injection and a vaccine therapy in conjunction with irradiated tumor cells against melanoma in the murine B16 melanoma model. The transfection process did not adversely alter the function of the wild-type (WT) BCG. rBCG 3A and WT BCG are equally effective intratumoral and vaccine therapies against melanoma when compared with normal saline control groups. Tumor burdens were significantly smaller (p < or = 0.01 and 0.05) for the treatment groups for both intratumoral and vaccine administration of therapy. Immunization with rBCG 3A and WT BCG 14 days before a B16 challenge resulted in an approximately 45% smaller tumor burden when compared with controls. Novel therapies based on the immunogenic properties of melanoma combined with molecular technologies may offer promise for an effective and safe treatment of melanoma.

References

Jan 1, 1979·Journal of Surgical Oncology·J AventH F Seigler
Feb 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W ProctorH Shibata
Feb 1, 1992·Archives of Biochemistry and Biophysics·B B Aggarwal, E Pocsik
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T AokiT Honjo
Jul 1, 1992·Infection and Immunity·K HuygenM Goldman
Jul 1, 1992·Journal of Surgical Oncology·E G EliasB S Buda
Jan 11, 1992·Annals of Plastic Surgery·C L Slingluff, H F Seigler
Dec 1, 1990·Infection and Immunity·K MatsuoT Yamada
Jun 6, 1991·Nature·C K StoverG F Hatfull
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P A SteerenbergE J Ruitenberg
May 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I C QuirtA R Willan
Jul 1, 1990·Cancer Metastasis Reviews·J C Bystryn
Nov 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D BerdM J Mastrangelo
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y WatanabeT Sakata
Jan 1, 1987·The Journal of Urology·T L RatliffW J Catalona
Jun 1, 1983·Journal of Surgical Oncology·M J ByrneC D Holman

❮ Previous
Next ❯

Citations

Aug 14, 2019·Applied Microbiology and Biotechnology·Martha Lucia Ruiz BenitezFabiana Kömmling Seixas
Nov 20, 2004·Immunology and Cell Biology·Circe Mesa, Luis E Fernández
Jun 19, 2001·Biological Chemistry·H MollenkopfS H Kaufmann
Aug 30, 2008·Expert Opinion on Drug Delivery·Yin Hwa Lai, Chong Wang
Jun 8, 2015·Cancer Immunology, Immunotherapy : CII·Manisha Singh, Willem W Overwijk
Apr 28, 2010·Expert Opinion on Biological Therapy·Shifang YuanWei Han
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chie Kudo-SaitoJames W Hodge
Jul 6, 2021·Expert Review of Vaccines·Lazaro M Marques-NetoLuciana C C Leite

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.