Recombinant bovine interferon-gamma as an immunomodulator in dexamethasone-treated and nontreated cattle

Journal of Interferon Research
J A Roth, D E Frank

Abstract

Three dosages (0.1, 0.5, and 2.5 mg/animal, subcutaneously), of recombinant bovine interferon-gamma (rBoIFN-gamma) were evaluated for their in vivo influence on neutrophil function and lymphocyte blastogenesis in cattle. The optimal of the three dosages tested (0.5 mg/animal or 1.1 x 10(6) U/animal) was then evaluated for its influence on neutrophils and lymphocytes in both normal and dexamethasone-treated cattle. One animal, which received 2.5 mg of rBoIFN-gamma, died by 24 h after administration due to acute diffuse interstitial pneumonia with interlobular edema and emphysema. The two highest dosages used caused fever at 24 h and the highest dosage caused a decrease in lymphocyte blastogenesis at 24 h after administration. The influence of rBoIFN-gamma on neutrophil function was dose dependent and depended on the baseline values for neutrophil function. Random migration by neutrophils was consistently inhibited in animals that received 0.5 mg or more of rBoIFN-gamma. Staphylococcus aureus ingestion and antibody-dependent cell-mediated cytotoxicity by neutrophils was enhanced by rBoIFN-gamma treatment in both dexamethasone-treated cattle and in nondexamethasone-treated cattle, which had relatively low values for these paramete...Continue Reading

Citations

Feb 1, 1990·Veterinary Immunology and Immunopathology·R C Weiss, T Oostrom-Ram
Sep 1, 1991·Veterinary Immunology and Immunopathology·Y W ChiangJ A Roth
Jul 1, 1993·The British Veterinary Journal·C J McInnes
Dec 22, 1999·Veterinary Microbiology·H SentsuiY Yokomizo
Jun 20, 2006·Veterinary Immunology and Immunopathology·Alfonso De la MoraFrancisco Suárez-Güemes
Apr 10, 2003·The Veterinary Clinics of North America. Food Animal Practice·Jeanne L Burton, Ronald J Erskine
Oct 20, 2000·The Journal of General Virology·C RaggoP Griebel
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Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A IwataS Ueda
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Jul 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Frank H GaertnerPhilip J Griebel

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