PMID: 11604166Oct 18, 2001Paper

Recombinant canine IL-13 receptor alpha2-Fc fusion protein inhibits canine allergen-specific-IgE production in vitro by peripheral blood mononuclear cells from allergic dogs

Veterinary Immunology and Immunopathology
Liang TangCatherine McCall

Abstract

Human IL-13, like IL-4, is involved in the regulation of B-cell development, IgE synthesis and allergic responses. However, because IL-13 does not affect either murine Ig class switching or IgE production in vitro, the use of murine models to study the role of IL-13 in IgE-mediated diseases has been limited. In this communication, we report that recombinant protein of canine IL-13 (rcaIL-13) stimulates production of allergen-specific-IgE in vitro by peripheral blood mononuclear cells (PBMC) from flea allergen-sensitized dogs, and that this stimulation activity is specifically inhibited by recombinant protein of canine IL-13Ralpha2 and Fc fragment of canine IgG heavy chain (rcaIL-13Ralpha2-Fc). The data suggest that the regulatory effects of IL-13 on IgE production in canine PBMC are similar to those reported in humans. Thus, canine IL-13 may be a central mediator of allergic diseases in dogs, and allergic dogs may be excellent models for research on IgE-mediated diseases in humans.

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Jul 18, 2001·Veterinary Immunology and Immunopathology·L TangC McCall

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Citations

Sep 22, 2007·The Journal of Clinical Investigation·Mark S WilsonThomas A Wynn
Feb 11, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert V LumsdenMichael P Keane

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