Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Ton LismanPhilip G de Groot

Abstract

Cirrhosis is associated with a bleeding tendency, which is particularly pronounced during orthotopic liver transplantation (OLT). A novel approach to treating the bleeding diathesis of patients with cirrhosis is administration of recombinant factor VIIa (rFVIIa). This study examined whether the efficacy of rFVIIa in cirrhosis might be explained in part by enhanced down-regulation of fibrinolysis by thrombin-activatable fibrinolysis inhibitor (TAFI). Addition of therapeutic or supratherapeutic doses of rFVIIa to plasma of 12 patients with stable cirrhosis did not result in a prolongation of clot lysis time, though clotting times were significantly reduced. Also, clot lysis assays of plasma samples taken during and after OLT, which was performed with or without a single bolus dose of rFVIIa, did not show any effect of rFVIIa on plasma fibrinolytic potential. In conclusion, this study shows no evidence for an antifibrinolytic effect of rFVIIa in cirrhotic patients or in patients undergoing OLT.

References

Dec 2, 1976·Biochimica Et Biophysica Acta·J BrunnerH Hauser
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C F Scott, R W Colman
Aug 1, 1989·Gastroenterology·R J PorteF A Bontempo
Mar 1, 1986·Gut·D A Kelly, E G Tuddenham
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Nov 1, 1995·The Journal of Clinical Investigation·A RedlitzE F Plow
Jun 16, 1995·The Journal of Biological Chemistry·L BajzarM E Nesheim
May 1, 1994·The Medical Clinics of North America·E F Mammen
Sep 1, 1993·The Journal of Clinical Investigation·H ten CateR D Rosenberg
Oct 1, 1996·Mayo Clinic Proceedings·L R Roberts, P S Kamath
Dec 24, 1997·British Journal of Haematology·D M MonroeH R Roberts
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S I Rapaport
Dec 29, 2000·Seminars in Thrombosis and Hemostasis·P L Gross, W C Aird

❮ Previous
Next ❯

Citations

Jun 19, 2004·International Anesthesiology Clinics·Yves Ozier, Aline Albi
Jul 13, 2006·International Anesthesiology Clinics·Neville M Gibbs
Sep 29, 2007·Critical Care Medicine·R Todd StravitzUNKNOWN Acute Liver Failure Study Group
Jul 17, 2004·Current Opinion in Hematology·Erik J Uhlmann, Charles S Eby
Jun 11, 2005·Journal of Gastroenterology and Hepatology·David H Van ThielMagdalene M George
Jan 31, 2004·American Journal of Clinical Pathology·Madhu V MidathadaLouis M Fink
Jun 27, 2009·Acta neurochirurgica·Ruediger GerlachKlaus Goerlinger
Aug 8, 2008·Current Opinion in Organ Transplantation·Claus-Georg Krenn, Andre M De Wolf
Jul 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Massimo FranchiniGiuseppe Lippi
Feb 26, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Oliver FlowerDorrilyn Rajbhandari
Dec 24, 2005·Expert Opinion on Pharmacotherapy·Thomas G DeLoughery
Jul 9, 2013·Critical Care Clinics·Saumya JayakumarConstantine J Karvellas
Feb 21, 2009·Journal of the American College of Surgeons·Deborah M SteinThomas M Scalea
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jaime BoschUNKNOWN International Study Group on rFVIIa in UGI Hemorrhage
Aug 19, 2007·Transplantation Proceedings·F PuglieseP Pietropaoli
Jan 30, 2007·Hematology/oncology Clinics of North America·Lisa Payne Rojkjaer, Rasmus Rojkjaer
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellB Gail Macik
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·J C Reverter
Mar 16, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Freeha ArshadRobert J Porte
May 2, 2006·Transplantation Proceedings·J da Silva Viana
Jan 3, 2006·Transplantation Proceedings·B GalaM Gómez
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vanessa M ShamiB Gail Macik
Mar 24, 2005·The Annals of Pharmacotherapy·Masha S H Lam, Rosalyn P Sims-McCallum
Jan 30, 2007·Hematology/oncology Clinics of North America·George L AdamsJeffrey H Lawson
Aug 2, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Laura C BurlageTon Lisman
Aug 26, 2004·Blood·Harold R RobertsGilbert C White
May 1, 2004·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·W Sapsford
Jul 25, 2018·World Journal of Gastroenterology : WJG·Lesley De PietriMarco Vivarelli
Dec 17, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maureen J M WernerRobert J Porte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Seminars in Thrombosis and Hemostasis
G HimmelreichH Riess
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Marco SenzoloValeria Rossetto
Journal of Cardiothoracic and Vascular Anesthesia
Luc MassicotteLynda Thibeault
© 2021 Meta ULC. All rights reserved