Recombinant hirudin for prevention of experimental postoperative intraocular fibrin

American Journal of Ophthalmology
M A NasirR A Mittra

Abstract

To determine the efficacy of a specific antithrombin agent (recombinant desulphatohirudin variant 1 [Revasc, Ciba-Geigy, Ltd., Basel, Switzerland]) administered in the infusion fluid to prevent early postoperative fibrin formation in a rabbit lensectomy and vitrectomy model. Standard fragmatome lensectomies and core vitrectomies were performed prospectively in a masked fashion on ten control eyes with lactated Ringer's infusion and on ten eyes treated with 10 microgram of recombinant hirudin/ml in the infusate. The amounts of fibrin and hemorrhage were graded in a masked fashion by using slit-lamp examination and indirect ophthalmoscopy on postoperative days 1 through 5 and on day 7. The difference in the mean grade of fibrin formed on the first postoperative day in the eyes treated with recombinant hirudin (mean, 0.9) in relation to the mean grade of fibrin in the control eyes (mean, 3.5) was statistically significant (P = .004). This difference was also significant on the second postoperative day (P = .01). None of the treated eyes developed intraoperative or postoperative hemorrhage. Recombinant desulphatohirudin variant 1 is an effective inhibitor of postoperative fibrin formation in a rabbit model and is not associated wit...Continue Reading

References

Jan 1, 1975·Annual Review of Biochemistry·E W Davie, K Fujikawa
Jan 1, 1991·Haemostasis·F Markwardt
Jan 1, 1991·Haemostasis·G Nowak, F Markwardt
Jan 1, 1991·Haemostasis·F MarkwardtE Bucha
Dec 15, 1990·Thrombosis Research·E BuchaG Nowak
Feb 1, 1990·Ophthalmology·G J JaffeD P Han
Oct 15, 1990·American Journal of Ophthalmology·C K DabbsA R Ward
Aug 15, 1989·American Journal of Ophthalmology·G J JaffeG W Abrams
Aug 1, 1988·Archives of Ophthalmology·G A WilliamsG W Abrams
Jun 1, 1987·Ophthalmology·R N JohnsonW H Stern
Sep 1, 1984·Archives of Ophthalmology·J S Vidaurri-Leal, B M Glaser

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