Recombinant human activated protein C for severe sepsis in neonates

The Cochrane Database of Systematic Reviews
Ranjit I Kylat, A Ohlsson

Abstract

Sepsis is a common problem in both preterm and term infants. Although the overall incidence of neonatal sepsis has declined over the past decade, mortality remains high. Recombinant human activated protein C (rhAPC) has been shown to possess a broad spectrum of activity modulating coagulation and has been shown in septic adults to reduce mortality. In septic children, an open label study has shown similar pharmacokinetics, adverse reaction profile and frequency as in adults with severe sepsis. To determine whether treatment with rhAPC will reduce mortality and/or morbidity in neonates with severe sepsis. Searches were carried out in July 2005 by the review authors independently of MEDLINE (1966 to July 2005), EMBASE (1980 to July 2005), CINAHL (1982 to July 2005), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 3, 2005), abstracts of annual meetings of the Pediatric Academic Societies and Society for Pediatric Research which were published in Pediatric Research from 1980, and contacts were made with subject experts. Doctoral dissertations, theses and the Science Citation Index for articles on activated protein C were searched from 1980. No language restriction was applied. Studies were i...Continue Reading

Associated Clinical Trials

Citations

Oct 13, 2006·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo Bellomo, Sean M Bagshaw
Oct 2, 2007·Critical Care : the Official Journal of the Critical Care Forum·Wendy A LuceJohn Anthony Bauer
Sep 24, 2009·Vascular Health and Risk Management·Doris FischerAlex Veldman
Sep 5, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·J L WynnO Levy
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Ranjit I Kylat, Arne Ohlsson
Jul 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dong WangPeng Xu

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