Recombinant human bone morphogenetic protein type 2 application for a possible treatment of bisphosphonates-related osteonecrosis of the jaw

The Journal of Craniofacial Surgery
Marco CicciùEnrico Stoffella

Abstract

Bisphosphonates are a class of agents used for treating osteoporosis and malignant bone metastases treatment. Osteonecrosis of the jaws is the main complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy can cause exposed and necrotic bone that is isolated to the jaw. This clinical investigation is aimed at analyzing the clinical effect of recombinant human bone morphogenetic protein type 2 (rhBMP-2) application in patients affected by bisphosphonates-related osteonecrosis of the jaws undergoing surgery for necrotic bone removal.A case review was made of 20 patients. The rhBMP-2 in all the cases reported here was used alone with the collagen carrier without concomitant bone materials. The cases involved osteonecrotic lesions of the upper and lower jaws. A total dose of 4 to 8 mg of rhBMP-2 was delivered to the surgical site in concentrations of 1.5 mg/mL (depending on the size of lesion). Patients were followed up over a period ranging 6 to 12 months.Patients had successful healing of the necrotic area. New bone formation in the surgical area could be clinically evaluated by palpation at the end of 3 to 4 months and confirmed by radi...Continue Reading

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Citations

Aug 1, 2015·Journal of Maxillofacial and Oral Surgery·Vijay Kumar, Raman Kant Sinha
Aug 29, 2012·Maturitas·Vivien Lim, Bart L Clarke
Dec 15, 2015·Oral and Maxillofacial Surgery·Larissa Fernandes SilvaMarcos Martins Curi
Aug 11, 2015·Maturitas·Nicole M Iñiguez-Ariza, Bart L Clarke
Jul 11, 2013·Clinical Implant Dentistry and Related Research·Henning Schliephake
Jul 23, 2016·Maxillofacial Plastic and Reconstructive Surgery·Doo Yeon HwangSeung Ii Song
Jan 7, 2017·The Journal of Craniofacial Surgery·Tommaso Bucci, Pier Francesco Nocini
Jan 4, 2017·The Journal of Craniofacial Surgery·Leonardo Matos Santolim ZanettiniRogério Miranda Pagnoncelli
Dec 16, 2016·The Journal of Craniofacial Surgery·Seda YilmazBerrin Zuhal Altunkaynak
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