Recombinant human erythropoietin as an adjunct to radiation therapy and cisplatin for stage IIB-IVA carcinoma of the cervix: a Southwest Oncology Group study

Gynecologic Oncology
R S LaveyD S Alberts

Abstract

The survival of cervix cancer patients is associated with their hemoglobin (Hgb) level during radiotherapy. The Southwest Oncology Group (SWOG) conducted a phase II trial to determine whether recombinant human erythropoietin (rHuEPO) safely corrects anemia during chemoradiotherapy for cervix cancer. Patients had stage IIB-IVA cervix cancer and a Hgb between 8.0 and 12.5 g/dl. All patients received rHuEPO thrice weekly and oral iron starting 10-15 days before their 5-week course of whole pelvic irradiation and weekly cisplatin followed by intracavitary brachytherapy. Fifty-three patients from 26 institutions received the protocol treatment. The mean Hgb was 10.4 +/- 1.3 g/dl on the first day of rHuEPO administration (baseline), 11.0 +/- 1.6 g/dl on the first day of chemoradiotherapy, 11.6 +/- 1.9 g/dl at the midpoint of chemoradiotherapy, and 11.8 +/- 2.2 g/dl at the end of chemoradiotherapy. The target Hgb level of 12.5 g/dl was achieved in 40% of patients (95% CI 26-56%) by the midpoint of Chemoradiotheraphy. Change in Hgb was associated with baseline serum iron (P = 0.008) and transferrin saturation (P = 0.05) levels, but not with baseline Hgb or serum ferritin, or patient age. Seven patients developed deep vein thrombosis. T...Continue Reading

References

Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J OvergaardI Löftquist
Dec 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·L S FreedmanJ M Henk
Nov 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R S Bush
Apr 1, 1983·The British Journal of Radiology·S DischeE R Watson
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·M Werner-WasikH Madoc-Jones
Jun 1, 1995·American Journal of Public Health·D T JanerichA P Polednak
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·K E DusenberyR A Potish
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·R S Lavey, W H Dempsey
Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·H C HsuH C Chen
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Juergen DunstGabriele Haensgen
Jul 3, 2003·Journal of the National Cancer Institute
Aug 7, 2003·The Lancet Oncology·Brian Leyland-Jones, UNKNOWN BEST Investigators and Study Group
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael AuerbachJeevindra Rana

❮ Previous
Next ❯

Citations

May 27, 2005·Gynecologic Oncology·Robert S Lavey
Apr 12, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C MarchalC Brunaud
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·X WangJ J Kavanagh
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y S ChoiT S Lee
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S M TemkinO Abulafia
Mar 17, 2009·Best Practice & Research. Clinical Haematology·Ted Wun, Richard H White
Nov 21, 2007·Thrombosis Research·Giancarlo Agnelli, Melina Verso
Dec 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C BokemeyerUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Taskforce for the Elderly
Jan 4, 2006·Thrombosis Research·Tufia C Haddad, Edward W Greeno
Mar 21, 2007·Gynecologic Oncology·Jennifer F De Los Santos, Gillian M Thomas
Aug 24, 2007·Expert Opinion on Pharmacotherapy·Leo R Zacharski, Cocav A Engman
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley J MonkWui-Jin Koh
Sep 18, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jennifer Nishioka, Susan Goodin
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Thomy ToniaJulia Bohlius
Aug 12, 2005·Current Opinion in Oncology·Luis A Rojas-Espaillat, Peter G Rose
Oct 12, 2007·Journal of Applied Microbiology·J Palma-GuerreroL V Lopez-Llorca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.