PMID: 8600865Mar 1, 1996Paper

Recombinant human erythropoietin: effect on the functional performance of anemic orthopedic patients

Archives of Physical Medicine and Rehabilitation
D GreenD Ronin

Abstract

To determine whether rapid correction of anemia improves the functional and cognitive performance of postoperative orthopedic patients. A randomized, double-blind, placebo-controlled clinical trial. A rehabilitation institute. Persons having orthopedic surgery at least 2 weeks previously, and a hemoglobin concentration < 10g/dL. Recombinant human erythropoietin (rH-EPO) or the EPO vehicle for up to 8 weeks. All patients received ferrous sulfate. Blood counts were performed at weekly intervals, and functional and cognitive tests at baseline and weeks 4 and 8. In patients receiving vehicle only, hemoglobin levels increased from a mean of 9.0 at baseline to 11.0 at 4 weeks and 11.7 at 8 weeks; corresponding values for rH-EPO were 8.8 (p = NS), 12.6 (p = .02), and 13.5 (p = .01). However, functional improvement in dressing, toileting, and mobility was similar between groups, and the results of neuropsychological tests showed no trends favoring rH-EPO. Although hemoglobin increases more rapidly in anemic orthopedic patients treated with rH-EPO, equally rapid functional improvement occurs in those who receive only iron therapy.

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Citations

Feb 15, 2002·British Journal of Haematology·C E van IperenJ J Marx
Aug 1, 2006·The Journal of Arthroplasty·Paul T DiamondKiran Bhirangi
Mar 31, 2004·The American Journal of Medicine·Aryeh ShanderRichard Spence
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Aug 20, 2002·The Oncologist·Michael S Gordon
Jan 24, 2002·American Journal of Physical Medicine & Rehabilitation·P T Diamond, D M Julian
Nov 30, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yasuyuki SatoSyu Kawashima

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