Recombinant human erythropoietin prevents the death of mice during cerebral malaria

The Journal of Infectious Diseases
Karine KaiserStéphane Picot

Abstract

Cerebral involvement during malaria is a complication that leads to seizure, coma, and death. The effect of new neuroprotective therapies has not yet been investigated, although cerebral malaria shares some features with neurological stroke. Erythropoietin (EPO) is one of the more promising drugs in this area. We measured the effect of EPO on the survival of mice infected with Plasmodium berghei ANKA and demonstrated that inoculations of recombinant human EPO at the beginning of the clinical manifestations of cerebral malaria protect >90% of mice from death. This drug has no effect on the course of parasitemia. The effect of EPO was not related to either the inhibition of apoptosis in the brain or the regulation of the increase and decrease of nitric oxide production in the brain and blood, respectively. Tumor necrosis factor-alpha and interferon-gamma mRNA overexpression was inhibited by EPO, and treated mice had fewer brain hemorrhages. EPO has been used in patients with chronic diseases for years, and more recently it has been used to treat acute ischemic stroke. The data presented here provide the first evidence indicating that this cytokine could be useful for the symptomatic prevention of mortality during the acute stage ...Continue Reading

Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna-Leena SirénHannelore Ehrenreich
Feb 8, 2013·Nature Medicine·Louis H MillerThomas E Wellems
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie-France PenetBouchra Gharib
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Climent Casals-PascualCharles R J C Newton
Mar 19, 2011·The Journal of Infectious Diseases·Pedro CabralesLeonardo J M Carvalho
May 25, 2012·Science Translational Medicine·Ariel H AchtmanLouis Schofield
Sep 10, 2008·Antimicrobial Agents and Chemotherapy·Anne-Lise Bienvenu, Stéphane Picot
Dec 15, 2010·Infection and Immunity·Miranda S OakleySanjai Kumar
Nov 1, 2008·Therapeutic Advances in Neurological Disorders·Claudia BartelsHannelore Ehrenreich
Jul 28, 2009·Malaria Journal·Stéphane PicotOgobara K Doumbo
Nov 26, 2009·Malaria Journal·Isabelle M MedanaGareth D H Turner
Nov 19, 2010·Parasites & Vectors·Anne-Lise BienvenuStephane Picot
May 23, 2013·PLoS Pathogens·Steve M TaylorRick M Fairhurst
Dec 21, 2011·Molecular Medicine·Michael Brines, Anthony Cerami
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kenneth MaieseYan Chen Shang
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Angela O'DonnellD J Weatherall
Sep 18, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Estela ShabaniChandy C John
Aug 25, 2015·International Journal for Parasitology·Dominique F LeitnerJames R Connor
May 31, 2011·Best Practice & Research. Clinical Anaesthesiology·Derya SarginHannelore Ehrenreich
Nov 15, 2008·Trends in Parasitology·Climent Casals-PascualCharles R J C Newton
Apr 9, 2008·Progress in Neurobiology·Kenneth MaieseYan Chen Shang
Mar 18, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kenneth Maiese
Mar 25, 2008·Acta Tropica·Anne-Lise BienvenuStéphane Picot
Dec 20, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hannelore EhrenreichHenning Krampe
Aug 23, 2011·The American Journal of Pathology·Casper HempelGeorges Emile Raymond Grau
Nov 6, 2015·Mediators of Inflammation·Gisele Aparecida LocachevicLúcia Helena Faccioli
Aug 29, 2006·International Journal for Parasitology·Sapan B ParekhCaroline Rae
Nov 19, 2011·Microbes and Infection·Manfred NairzGünter Weiss
Jan 31, 2012·Journal of Tropical Medicine·Dewaldt EngelbrechtThérèsa Louise Coetzer
Sep 13, 2011·Expert Review of Anti-infective Therapy·Sarah J HigginsW Conrad Liles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.