PMID: 8603013Feb 1, 1996Paper

Recombinant human G-CSF-mobilized peripheral blood stem cells for second allogeneic transplant after bone marrow graft rejection in children

British Journal of Haematology
M ZeccaF Locatelli

Abstract

Two children affected by severe aplastic anaemia and sickle cell anaemia rejected the allogeneic bone marrow transplantation from an HLA-matched unrelated volunteer and an HLA-identical sibling, respectively. In both cases a second transplant using granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC) was performed. Donors were the HLA-haploidentical mother and the same HLA-identical sibling who was employed for the first marrow allograft, respectively. Treatment with G-CSF and PBSC collection were well tolerated. Both patients had engraftment of donor haemopoiesis and did not experience severe graft-versus-host disease. These cases confirm that PBSC transplant should be considered as a feasible treatment to reverse graft failure in paediatric patients.

Citations

Dec 21, 2000·British Journal of Haematology·P G SchlegelT Klingebiel
Nov 10, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shimon SlavinTibor Bakacs
Sep 22, 2007·Blood Cells, Molecules & Diseases·Peter LangRupert Handgretinger
Apr 2, 2002·Best Practice & Research. Clinical Haematology·P J Henslee-Downey
Oct 26, 2013·Expert Opinion on Pharmacotherapy·Franco LocatelliPietro Merli
Oct 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joseph H ChewningFarid Boulad
Dec 26, 2001·Bone Marrow Transplantation·C R de MedeirosR Pasquini
Dec 15, 2017·European Journal of Haematology·Hassan A AljasemFotios V Michelis

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