Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous infusions of large volumes of immunoglobulin in a swine model

Drug Delivery and Translational Research
David W KangMonica L Zepeda

Abstract

Many patients with primary immunodeficiency disease (PIDD) require lifelong immunoglobulin (Ig) replacement therapy. Home-based subcutaneous (SC) infusion provides advantages to patients with PIDD compared to hospital-based intravenous infusion. One limitation of current practice with SCIg infusion is the need for small-volume infusions at multiple injection sites on a frequent basis. A method was developed for large-volume SC infusion that uses preinfusion of recombinant human hyaluronidase (rHuPH20) to facilitate fluid dispersion. Miniature swine was used as a preclinical model to assess the effects of rHuPH20-facilitated infusions, of a single monthly dose, on fluid dispersion, infusion-related pressure, swelling, induration, and tissue damage. Preinfusion of vehicle (control) or rHuPH20 (75 U/g Ig) was performed simultaneously on contralateral abdominal sites on each animal, followed by infusion of 300 mL 10 % Ig (30 g) at each site. Compared to control infusions, rHuPH20 significantly reduced infusion pressure and induration (p < 0.05) and accelerated postinfusion Ig dispersion. Histological evaluation of infusion site tissue showed moderate to severe swelling for the control. Swelling after rHuPH20-facilitated infusion wa...Continue Reading

References

Jan 1, 1981·Journal of Biomechanics·N P Reddy, G V Cochran
Jun 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·A J LeuA Bollinger
Nov 14, 1998·Injury·M Mars, G P Hadley
Aug 8, 2001·Advanced Drug Delivery Reviews·C J PorterS A Charman
Mar 26, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dirk UhlmannHelmut Witzigmann
Jun 23, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Melvin Berger
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Ann GardulfMichael Borte
May 23, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jörg Andreas MahlVicente Nogués
May 27, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ove Svendsen
Jun 20, 2006·Journal of Clinical Immunology·Hans D OchsUNKNOWN Subcutaneous IgG Study Group
Jun 20, 2006·Journal of Clinical Immunology·J M KittnerR E Schmidt
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·L H BookbinderG I Frost
Apr 4, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Ann Gardulf
Oct 23, 2008·Immunology and Allergy Clinics of North America·Melvin Berger
Oct 30, 2008·Molecular Pain·Andre LaferrièreTerence J Coderre
Jan 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sharath GollaKhaled A M Gasem
Nov 4, 2009·Clinical and Experimental Immunology·S MisbahH D Ochs
Sep 15, 2005·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Akhilesh ChoukseyMelvin Berger
Jul 6, 2010·Journal of Pharmacological and Toxicological Methods·Jan Willem van der LaanUNKNOWN Steering Group of the RETHINK Project
Feb 18, 2011·The Journal of Surgical Research·John KalnsStephen Fecura
Apr 26, 2011·The Journal of Allergy and Clinical Immunology·Nima RezaeiKim E Nichols

❮ Previous
Next ❯

Citations

Aug 20, 2015·Clinical and Experimental Immunology·M PonsfordS Jolles
May 15, 2015·The AAPS Journal·Sanna RosengrenDouglas B Muchmore
Nov 1, 2016·Journal of Clinical Immunology·Emily CarneStephen Jolles
Feb 15, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sanna RosengrenBarry J Sugarman
Aug 5, 2020·Expert Opinion on Biological Therapy·Barry PaulSaad Z Usmani
Apr 30, 2014·Advances in Hematology·Emma Conway O'BrienTimothy Chevassut
Jul 14, 2020·Expert Review of Hematology·Barry PaulSaad Z Usmani
Feb 23, 2021·Journal of Medicinal Chemistry·Dean G Brown, Heike J Wobst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.