Recombinant human insulin-like growth factor I, recombinant human growth hormone, and sex steroids: effects on markers of bone turnover in humans

The Journal of Clinical Endocrinology and Metabolism
N MaurasJ R Shapiro

Abstract

Sex steroids, GH, and insulin-like growth factor I (IGF-I) have all been shown to be highly anabolic in bone. Using available markers of bone formation, we measured the changes in serum concentrations of carboxy-terminal propeptide of type I collagen (PICP) and osteocalcin in five groups of subjects given different bone anabolic hormones: group I (five males and three females; mean +/- SE age, 25 +/- 2 yr) received recombinant human IGF-I (rhIGF-I) as a constant 28-h infusion i.v. (5-10 micrograms/kg.h); group II (three males and two females; 25 +/- 2 yr) received rhIGF-I (100 micrograms/kg, sc, twice daily) for 5-7 days; group III (five males; 28 +/- 2 yr) received rhGH (0.025 mg/kg.day, sc, for 7 days, alone (group IIIa) or followed by a 28-h sc infusion of rhIGF-I (10 micrograms/kg.h) in addition to rhGH (group IIIb); group IV (six prepubertal boys; 13 +/- 0.6 yr) received testosterone enanthate (100 mg, im) twice over 4 weeks; and group V (five hypogonadal girls with Turner's syndrome) received different forms of estrogen for 4 weeks. Most groups (except for III) had deoxypyridinoline concentrations (a marker of bone resorption) measured in urine as well. Each subject served as his/her own control. rhIGF-I treated subjects ...Continue Reading

Citations

Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Sep 27, 2015·Molecular and Cellular Endocrinology·Richard C Lindsey, Subburaman Mohan
Jul 1, 2012·Asian-Australasian Journal of Animal Sciences·Cheng-Yung LinTien-Chun Wan
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·A MayoS F Ahmed

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