Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth hormone pulsatility in young adults with type I diabetes mellitus

Metabolism: Clinical and Experimental
E C CrowneD B Dunger

Abstract

To investigate whether recombinant human insulin-like growth factor-I (rhIGF-I) has direct effects on the insulin requirement to maintain euglycemia independent of the growth hormone (GH) level, nine subjects with insulin-dependent diabetes mellitus ([IDDM] seven females; median (range) age, duration of diabetes, and hemoglobin A1C [HbA1C], 16.9 (12.5 to 21.9) years, 11.8 (4.6 to 16.8) years, and 9.8% (7.9% to 14.1%), respectively) underwent two euglycemic studies (6:00 PM to 8:00 AM) after double-blind subcutaneous administration of rhIGF-I/placebo (40 microg/kg). Octreotide infusion (300 ng/kg/h) suppressed endogenous GH, and three identical discrete GH pulses were infused on both nights. Variable-rate insulin infusion maintained euglycemia. Samples were taken every 15 minutes (glucose and GH), 30 minutes (insulin and intermediate metabolites), and 60 minutes (IGF-I and nonesterified fatty acids [NEFA]). Variables were analyzed during the steady-state period of euglycemia (4:00 to 8:00 AM). Data are expressed as the mean +/- SEM. The insulin infusion rate and free-insulin level were both significantly reduced after rhIGF-I administration (0.13 +/- 0.03 v placebo 0.23 +/- 0.05 mU/kg/min, P = .04, and 8.4 +/- 1.3 v placebo 12.1...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J A BatchG Werther
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J A EdgeC P Smith
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J BolinderP Arner
Jul 24, 1986·The New England Journal of Medicine·S A AmielW V Tamborlane
Apr 1, 1985·Diabetes·J R BrennanW G Blackard

❮ Previous
Next ❯

Citations

Mar 12, 2005·Hormone Research·David DungerKen Ong
May 12, 2005·Hormone Research·Robert J FerryLorraine E Levitt Katz
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Apr 21, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kevin C J Yuen, David B Dunger
Mar 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Rachel M WilliamsDavid B Dunger
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Rakesh Amin, David B Dunger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.