PMID: 2108803Jan 1, 1990Paper

Recombinant human interferon gamma exerts an anti-proliferative effect and modulates the expression of human leukocyte antigens A,B,C and DR in human urothelial cell lines

Cancer Immunology, Immunotherapy : CII
S S OttesenJ Kieler

Abstract

In this study we have treated three malignant (TGrIII) and two pre-malignant (TGrII) urothelial cell lines with recombinant human interferon gamma (rHu-INF gamma). The malignant cells (HCV29-T112C1, Hu1703He and T24) were inhibited in growth by more than 50% after treatment with 100-1000 units of rHu-INF gamma/ml for 4 days as compared to untreated controls. The growth of the pre-malignant cell lines (HCV29 and Hu609) was not influenced to the same extent in the presence of rHu-INF gamma in the culture medium. Treatment with rHu-INF gamma increased the expression of monomorphic human leukocyte antigens (HLA) A,B,C as well as beta 2-microglobulin in all the cell lines tested, as demonstrated using a quantitative immunofluorescence assay. The tumourigenic cell lines increased their expression of HLA in a dose-dependent way, whereas treatment of the non-tumourigenic cells with higher concentrations of rHu-INF gamma than 10 units/ml, did not increase the HLA-A,B,C expression further. None of the cell lines expressed HLA-DR unless treated with rHu-INF gamma. No correlation between tumourigenicity and the dose of rHu-INF gamma required for "de novo" induction of HLA-DR could be demonstrated. After removal of rHu-INF gamma from the me...Continue Reading

References

Mar 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S S OttesenJ Kieler
Jan 1, 1987·Cancer Metastasis Reviews·M Shearer, J Taylor-Papadimitriou
Jan 1, 1988·Cancer Immunology, Immunotherapy : CII·S S OttesenJ Kieler
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·U FlatowA S Rabson
Jul 1, 1987·European Journal of Cancer & Clinical Oncology·S S OttesenB Christensen
Feb 15, 1985·International Journal of Cancer. Journal International Du Cancer·R SchwartzV Schirrmacher
Dec 24, 1981·Nature·A A Branca, C Baglioni
Jan 1, 1984·Cancer Metastasis Reviews·J F Kieler
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo

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Citations

Jul 17, 1998·British Journal of Urology·N E StavropoulosN J Agnantis
Jul 21, 2017·Nature·Chris ClarksonColin Pardoe
Sep 10, 2003·Journal of the American Veterinary Medical Association·Joanne E MacartneyCarl S Ribble
Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·K D Beaman
May 28, 1993·Annals of the New York Academy of Sciences·P Leanderson
Mar 4, 2000·The Urologic Clinics of North America·D H BrownR R Bahnson

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