Recombinant human leukemia inhibitory factor does not improve implantation and pregnancy outcomes after assisted reproductive techniques in women with recurrent unexplained implantation failure

Fertility and Sterility
Peter R BrinsdenPatrick Engrand

Abstract

In this randomized, double-blind, placebo-controlled, multicenter study, women (n = 149) with a history of at least two unexplained implantation failures after assisted reproductive techniques received recombinant human leukemia inhibitory factor, 150 microg SC twice daily for 7 days, or placebo. The clinical pregnancy rate after ET was significantly lower in patients receiving recombinant human leukemia inhibitory factor than in those receiving placebo (17.6% vs. 34.0%, respectively).

References

Feb 1, 1996·The Journal of Clinical Endocrinology and Metabolism·M J NachtigallA Arici
Nov 5, 1997·Annals of the New York Academy of Sciences·A BoriniC Flamigni

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Citations

Sep 15, 2012·Journal of Assisted Reproduction and Genetics·Alex Simon, Neri Laufer
Dec 12, 2012·Nature Medicine·Jeeyeon ChaSudhansu K Dey
Aug 24, 2010·Human Reproduction Update·Hakan Cakmak, Hugh S Taylor
Oct 2, 2013·Human Reproduction Update·Signe AltmäeAndres Salumets
Mar 11, 2010·Current Opinion in Obstetrics & Gynecology·Lusine Aghajanova
Jul 23, 2011·Genes & Cancer·Wenwei HuJiabei Wang
Jul 29, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·L MohametS J Kimber
Mar 4, 2014·Reproductive Biomedicine Online·Lukasz T PolanskiNicholas J Raine-Fenning
Oct 29, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Y GnainskyN Dekel
Dec 19, 2012·Fertility and Sterility·Stephen S Palmer, Kurt T Barnhart
Apr 3, 2012·Fertility and Sterility·Alex Simon, Neri Laufer
Jun 29, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J J Brosens, B Gellersen
Jul 19, 2015·Cytokine & Growth Factor Reviews·Nicos A Nicola, Jeffrey J Babon
May 29, 2012·Biochimica Et Biophysica Acta·Maria Ruiz-AlonsoCarlos Simón
Jun 12, 2012·Biochimica Et Biophysica Acta·Y E M KootN S Macklon
Aug 26, 2014·TheScientificWorldJournal·Naguib Salleh, Nelli Giribabu
Aug 3, 2016·Journal of Assisted Reproduction and Genetics·Wan-Tinn TehPeter Rogers
Dec 31, 2014·Endocrine Reviews·George A ThouasDavid K Gardner
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Jul 23, 2014·Molecular Endocrinology·Sandeep PawarMilan K Bagchi
Sep 8, 2011·Expert Review of Clinical Immunology·Udo R MarkertJustine S Fitzgerald
May 28, 2019·The International Journal of Neuropsychopharmacology·Hye Jeong LeeHyeon Soo Kim
Nov 30, 2019·Journal of Assisted Reproduction and Genetics·Jemma EvansLois A Salamonsen
Apr 5, 2020·Genes·Anna Idelevich, Felipe Vilella
May 4, 2010·Current Opinion in Obstetrics & Gynecology

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