PMID: 8599329Apr 1, 1996Paper

Recombinant human milk proteins - an opportunity and a challenge

The American Journal of Clinical Nutrition
B Lönnerdal

Abstract

Several human milk proteins have physiologic functions in infants. These proteins are involved in defense against infectious agents and in the optimization of nutrient uptake from milk. Therefore, interest in producing recombinant human milk proteins to use in infant formula has been growing. Microorganisms and transgenic animals can now be used for the production of bioactive proteins. However, the benefits of each protein must be evaluated in cells, animal models, and infants before claims can be made that adding them to formula improves the health or nutrition of infants. Once benefits are shown, proper manufacturing conditions must be developed for introducing the protein or proteins into formula. Processing conditions must be evaluated to ensure that biologic activity is maintained. Dry blending, aseptic processing, sterile filtration, and other techniques will likely be necessary for introducing proteins that require specific tertiary structure for activity. The importance of posttranslational modifications must also be considered: some proteins may require proper glycosylation or phosphorylation for physiologic activity.

Citations

Oct 6, 1997·Journal of Dairy Science·C N Karatzas, J D Turner
Dec 16, 1998·The British Journal of Nutrition·B KoletzkoS Strobel
May 6, 2003·The Journal of Nutrition·Bo Lönnerdal
Jun 20, 2002·Journal of the American College of Nutrition·Bo Lönnerdal
Nov 24, 1999·Acta Paediatrica. Supplement·J N Udall, R M Suskind
Oct 29, 2011·Evolutionary Anthropology·Katie Hinde, Lauren A Milligan
Mar 17, 2021·The Journal of Dairy Research·Roberta Claro da SilvaSalam A Ibrahim
Nov 13, 2004·The Journal of Nutritional Biochemistry·P A PrietoB Kelder
Aug 14, 2003·The Journal of Nutritional Biochemistry·Winyoo ChowanadisaiBo Lönnerdal

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