Recombinant human osteogenic protein-1 induces dentin formation: an experimental study in miniature swine

Journal of Endodontics
S JepsenD Rueger

Abstract

It was the aim of the present study to investigate the induction of dentin formation by recombinant human osteogenic protein-1 (hOP-1). In 4 adult miniature pigs a total of 16 teeth with artificially exposed dental pulps were capped with 3 mg of a complex of recombinant hOP-1 in collagen matrix (2.5 micrograms/mg), collagen matrix alone, or calcium hydroxide paste. Teeth were removed in block section after a healing period of 5 weeks. Decalcified sections were processed for light microscopy and histomorphometric analysis. In hOP-1 treated teeth substantial amounts of hard tissue formation (osteodentin and tubular dentin) had consistently led to a complete bridging of the defects. Less dentin formation was seen after calcium hydroxide application. In control defects collagen matrix alone failed to form complete dentin bridges. Recombinant human osteogenic protein-1 in a collagen carrier matrix appeared to be suitable as a bio-active capping agent for surgically exposed dental pulps.

References

Mar 1, 1991·Journal of Dental Research·K BesshoM Murata
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Jul 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D FinkelmanD J Baylink
Jun 1, 1989·Journal of Dental Research·T Kawai, M R Urist
Jan 1, 1987·The Journal of Prosthetic Dentistry·C F CoxG Bergenholtz
Dec 1, 1982·Journal of Oral Pathology·G BergenholtzS A Syed
Jul 1, 1993·Archives of Oral Biology·R B RutherfordM Charette

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Citations

Sep 19, 2000·Tissue Engineering·K A AthanasiouX Wang
Jun 6, 2012·International Journal of Dentistry·Xanthippi ChatzistavrouPetros Papagerakis
Dec 25, 2009·Journal of Oral Science·Shehab El-Din M Saber
Jul 28, 2012·Dental Clinics of North America·Sahng G KimJeremy J Mao
Mar 1, 2013·Endodontic Topics·Sahng G KimJeremy J Mao
Jul 27, 2005·Bone·Ingo N G SpringerHendrik Terheyden
Dec 13, 2006·Operative Dentistry·Jacques E Nör
Jun 29, 2010·Journal of Dentistry·Paul R CooperAnthony J Smith
Dec 21, 2016·Journal of Biomedical Materials Research. Part a·Wellington Luiz de Oliveira da RosaAdriana Fernandes da Silva
Sep 21, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J M GranjeiroR Taga
Mar 19, 2003·Advances in Dental Research·H LovschallA Flyvbjerg
Feb 7, 2018·International Endodontic Journal·W L O da RosaA F da Silva
Jan 25, 2006·International Journal of Paediatric Dentistry·V SrinivasanP J Waterhouse
Nov 30, 2012·Oral and Maxillofacial Surgery·Frank SchwarzJürgen Becker
Jan 1, 2013·Visual Culture in Britain·Keren Rosa Hammerschlag
Jun 6, 2020·Expert Opinion on Drug Delivery·Anil Kishen, Hebatullah Hussein
Apr 20, 2001·International Journal of Paediatric Dentistry·P J WaterhouseJ V Soames
Nov 5, 2015·Materials·Laetitia KellerFlorence Fioretti
Nov 1, 2006·Operative Dentistry·J E N R
Apr 27, 2011·Brazilian Dental Journal·Flávio Fernando DemarcoJacques Eduardo Nör
Nov 27, 2015·Dentistry Journal·Dimitrios Tziafas, Konstantinos Kodonas
Jan 28, 2003·Histochemistry and Cell Biology·Akihiro HosoyaHidehiro Ozawa
Jun 19, 2001·Primary Dental Care : Journal of the Faculty of General Dental Practitioners (UK)·C Scully
Sep 28, 2005·Journal of Endodontics·Misako Nakashima, Akifumi Akamine
Dec 25, 2007·Journal of Endodontics·Hikaru KaidaKatsumasa Maeda

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