Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects

Journal of Periodontology
William V GiannobileT C Chan

Abstract

Osteogenic protein-1 (OP-1) is a member of the transforming growth factor beta superfamily and is a potent modulator of osteogenesis and bone cell differentiation. This preclinical study in dogs sought to assess the effects of OP-1 on periodontal wound healing in surgically created critical size Class III furcation defects. Eighteen male beagle dogs were subjected to the creation of bilateral mandibular 5 mm osseous defects. A split-mouth design was utilized which randomly assigned opposing quadrants to control therapy (surgery alone or collagen vehicle) or 1 of 3 ascending concentrations of OP-1 in a collagen vehicle (0.75 mg OP-1/g collagen, 2.5 mg/g, or 7.5 mg/g). Thus, 9 quadrants per test group received OP-1, 9 quadrants per control group received surgery alone, and 9 quadrants received collagen vehicle alone. Test articles were delivered by a surgeon masked to the treatment, and fluorogenic bone labels were injected at specified intervals post-treatment. Eight weeks after defect creation and OP-1 delivery, tissue blocks of the mandibulae were taken for masked histomorphometric analysis to assess parameters of periodontal regeneration (e.g., bone height, bone area, new attachment formation, and percent of defect filled wit...Continue Reading

References

Jul 1, 1992·Journal of Periodontal Research·R B RutherfordM F Charette
Sep 1, 1989·Journal of Clinical Periodontology·S E LynchH N Antoniades
May 13, 1983·Science·M R UristG A Finerman
Jun 1, 1995·Journal of Periodontology·M I ChoR J Genco
May 1, 1995·The Journal of Bone and Joint Surgery. American Volume·S D CookD C Rueger
Mar 1, 1995·Journal of Clinical Periodontology·J M HaneyU M Wikesjö
Nov 1, 1994·Journal of Periodontal Research·U RipamontiA H Reddi
Jul 1, 1994·Journal of Periodontal Research·U Ripamonti, A H Reddi
Nov 1, 1993·Journal of Periodontal Research·R L MacNeil, M J Somerman
Jul 1, 1993·Archives of Oral Biology·R B RutherfordM Charette
Jul 1, 1996·Bone·W V Giannobile

❮ Previous
Next ❯

Citations

Apr 20, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiming JinWilliam V Giannobile
Jan 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Courtney A DunnWilliam V Giannobile
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Feb 13, 2001·Journal of Clinical Periodontology·S P LyngstadaasS Gestrelius
May 15, 2001·Journal of Clinical Periodontology·G N King, F J Hughes
Mar 30, 2006·Implant Dentistry·Hom-Lay Wang, Lakshmi Boyapati
Feb 24, 2000·Journal of Periodontal Research·M J SomermanW V Giannobile
Nov 6, 2009·Journal of Dental Research·G PellegriniW V Giannobile
Oct 26, 2006·Journal of Dental Research·J J MaoS Shi
Aug 23, 2008·Journal of Dental Research·J T KohR T Franceschi
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ming ZhaoMartha J Somerman
Apr 2, 2003·Journal of Periodontology·Q M JinW V Giannobile
Mar 18, 2004·Journal of Periodontology·Ming ZhaoMartha J Somerman
Dec 7, 2011·Medicina oral, patología oral y cirugía bucal·S SoodA Mahendra
Apr 14, 2015·Periodontology 2000·Mariano SanzSøren Jepsen
Apr 14, 2015·Periodontology 2000·Cristiano SusinUlf M E Wikesjö
Sep 5, 2006·Expert Opinion on Drug Delivery·Darnell KaiglerWilliam V Giannobile
Jan 27, 2012·Expert Opinion on Biological Therapy·Masahiro Saito, Takashi Tsuji
Jun 19, 2004·Connective Tissue Research·Q-M JinW V Giannobile
Oct 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fa-Ming ChenMin Zhang
Jan 28, 2010·Dental Clinics of North America·Jaebum LeeUlf M E Wikesjö
Nov 10, 2009·Cytokine & Growth Factor Reviews·Ugo Ripamonti, Jean-Claude Petit
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Ulf M E WikesjöMohammed Qahash
Dec 18, 2007·Micron : the International Research and Review Journal for Microscopy·João Paulo Mardegan IssaHelton Luiz Aparecido Defino
Oct 10, 2007·Micron : the International Research and Review Journal for Microscopy·João Paulo Mardegan IssaWalter Sebald
Oct 29, 2015·BioMed Research International·Fernando Suárez-López Del AmoHom-Lay Wang
May 15, 2007·Advanced Drug Delivery Reviews·Eduardo K MoioliJeremy J Mao
Mar 15, 2006·Dental Clinics of North America·Christoph A RamseierWilliam V Giannobile
Mar 15, 2006·Dental Clinics of North America·Taka Nakahara
May 13, 2005·Orthodontics & Craniofacial Research·M V Risbud, I M Shapiro
Aug 18, 2004·Journal of Clinical Periodontology·Rachel G SorensenJohn M Wozney
Jul 31, 2003·Journal of Clinical Periodontology·Ulf M E WikesjöW Ross Hardwick
Jul 31, 2003·Journal of Clinical Periodontology·Ulf M E WikesjöW Ross Hardwick
Sep 13, 2003·Clinical Oral Implants Research·Tae-Ju OhHom-Lay Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.