Recombinant human thyrotropin in veterinary medicine: current use and future perspectives

Journal of Veterinary Internal Medicine
M CamposS Daminet


Recombinant human thyrotropin (rhTSH) was developed after bovine thyrotropin (bTSH) was no longer commercially available. It was approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) as an aid to diagnostic follow-up of differentiated thyroid carcinoma in humans and for thyroid remnant ablation with radioiodine. In addition, rhTSH is used in human medicine to evaluate thyroid reserve capacity and to enhance radioiodine uptake in patients with metastatic thyroid cancer and multinodular goiter. Likewise, rhTSH has been used in veterinary medicine over the last decade. The most important veterinary use of rhTSH is thyroidal functional reserve testing for the diagnosis of canine hypothyroidism. Recent pilot studies performed at Ghent University in Belgium have investigated the use of rhTSH to optimize radioiodine treatment of canine thyroid carcinoma and feline hyperthyroidism. Radioiodine treatment optimization may allow a decreased therapeutic dosage of radioiodine and thus may improve radioprotection. This review outlines the current uses of rhTSH in human and veterinary medicine, emphasizing research performed in dogs and cats, as well as potential future applications.


Mar 1, 1992·The Journal of Endocrinology·C P VerschuerenT W de Bruin
Sep 20, 1991·Journal of Immunological Methods·T KashiwaiK Miyai
Sep 1, 1991·Journal of Veterinary Internal Medicine·A D Watson
Mar 1, 1991·Journal of Veterinary Internal Medicine·D S GrecoL W Shipman
Jul 1, 1989·Molecular and Cellular Endocrinology·D V HarbourW J Meyer
Dec 1, 1988·Australian Veterinary Journal·W F RobinsonR S Wyburn
Dec 31, 1987·Biochemical and Biophysical Research Communications·S WatanabeK Matsubara
Jul 1, 1987·Journal of Veterinary Internal Medicine·M E PetersonI Cavanagh
Apr 10, 1986·The New England Journal of Medicine·M Fisman
Aug 1, 1986·The Journal of Endocrinology·A LawC J Edmonds
Sep 2, 1985·FEBS Letters·Y HayashizakiK Matsubara
Sep 19, 1985·The New England Journal of Medicine·P BrownD M Asher
Feb 1, 1986·Molecular and Cellular Endocrinology·M NilssonL E Ericson
May 1, 1973·The Journal of Allergy and Clinical Immunology·C H KirkpatrickR R Rich
Nov 1, 1967·The Journal of Clinical Endocrinology and Metabolism·M T HaysG N Beall
Mar 1, 1967·Metabolism: Clinical and Experimental·J M Hershman
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·S MelmedW H Blahd
Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·C A MeierL J DeGroot
Mar 3, 1998·Nuclear Medicine Communications·L K Harding, W H Thomson
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·R M ColzaniC H Emerson
May 26, 1999·The Journal of Small Animal Practice·D L Panciera
Sep 29, 2001·Thyroid : Official Journal of the American Thyroid Association·R J RobbinsS M Larson
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·M BragaD S Cooper
Dec 28, 2002·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Ruthanne ChunJames J Hoskinson
Jan 30, 2003·Annals of Medicine·Nayahmka J McGriffNicholas J Sarlis
Feb 27, 2003·American Journal of Veterinary Research·Julie R StegemanJoe G Hauptman
May 14, 2003·Schweizer Archiv für Tierheilkunde·F S BorettiC E Reusch
Jun 5, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Barbara JarzabAleksander Zajusz
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Willy-Anne NieuwlaatAd R Hermus
Aug 2, 2003·Journal of Veterinary Internal Medicine·Sylvie Daminet, Duncan C Ferguson
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Daniel S Duick, H Jack Baskin
Sep 2, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S DaminetA De Rick
Oct 22, 2003·Cell·Deborah Veis Novack
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Steen J BonnemaLaszlo Hegedüs
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Bennett B ChinPaul Ladenson
Apr 9, 2004·Journal of the American Veterinary Medical Association·Charlotte H EdinboroLarry T Glickman
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Viveque E NielsenLaszlo Hegedüs
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Daniel S Duick, H Jack Baskin

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Jun 18, 2015·Journal of Veterinary Internal Medicine·T Y HuiJ C Scott-Moncrieff
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