Recombinant human TSH increases uptake and effective half-life of radioiodine in thyroid hormone secreting metastases of follicular thyroid cancer

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
C SchneiderC Kobe

Abstract

Follicular thyroid cancer with thyroid hormone secreting metastases is an extremely rare condition, with only a few cases reported world-wide. We here present the case of a 64-year-old female patient affected by follicular thyroid cancer with extensive thyroid hormone secreting metastases leading to TSH-suppression. We have also summarized the relevant diagnostic and therapeutic approaches and describe, for the first time, the effects of rhTSH-application in this rare tumor entity. In this patient, we found that rhTSH increased ¹³¹I-uptake into the thyroid hormone secreting metastases and prolonged the effective half-life of ¹³¹I. These effects of rhTSH should be considered when fixed activities of ¹³¹I are prescribed.

Citations

Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Joanna Klubo-GwiezdzinskaLeonard Wartofsky
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Debora ArpaiaBernadette Biondi
Jun 5, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christina SchneiderCarsten Kobe
May 21, 2020·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Tai Beishan SarahKelvin S H Loke

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