PMID: 8610142Apr 2, 1996Paper

Recombinant human uteroglobin suppresses cellular invasiveness via a novel class of high-affinity cell surface binding site

Proceedings of the National Academy of Sciences of the United States of America
G C KunduA B Mukherjee

Abstract

The mechanism(s) that regulates invasion of trophoblasts through the uterine epithelium during embryo implantation and nidation in hemochorial placental mammals is poorly understood. While limited trophoblast invasion is essential for the establishment of normal pregnancy, dysregulation of this process may contribute to the pathogenesis of choriocarcinoma, a highly invasive and lethal form of cancer arising from the trophoblasts. We have previously demonstrated that rabbit uteroglobin (UG), a cytokine-like, antiinflammatory protein, produced by the endometrial epithelium during pregnancy, has a potent antichemotactic effect on neutrophils and monocytes in vitro. Here, we report that recombinant human UG (hUG) dramatically suppresses invasion of human trophoblasts and NIH 3T3 cells through an artificial basement membrane (Matrigel) in vitro but has no effect on that of human choriocarcinoma cells. We identified a previously unreported high-affinity, high molecular weight (approximately 190 kDa), nonglycosylated hUG-binding protein, readily detectable on human trophoblasts and NIH 3T3 cells but totally lacking on choriocarcinoma cells. Taken together, these results raise the possibility that (i) hUG plays a critical role in regul...Continue Reading

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Citations

Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·D PandaA B Mukherjee
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z ZhangA B Mukherjee
Jan 1, 1997·DNA and Cell Biology·Z ZhangA B Mukherjee
Oct 9, 2013·Respiratory Research·Wei LiuZi-Qiang Luo
Aug 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Barry R StrippCharles G Plopper
Apr 21, 2001·Placenta·G J BurtonE Jauniaux
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Stephen B FritzJames R Baker
Jan 20, 2016·Expert Opinion on Therapeutic Targets·Maria E Laucho-ContrerasCaroline A Owen
Mar 30, 2004·Clinical Prostate Cancer·Steven R PatiernoJohn Patteras
Mar 14, 2007·Placenta·G J BurtonD S Charnock-Jones
Aug 19, 1999·The Journal of Pathology·E LeygueP H Watson
Jun 18, 2009·Current Opinion in Allergy and Clinical Immunology·Michael PlattKonstantina Stankovic
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Graham J BurtonEric Jauniaux
Apr 8, 2006·Endocrinology·Alexander TurchinGordon H Williams
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suil KimJay A Nadel
Feb 24, 2001·Annals of the New York Academy of Sciences·N PattabiramanA B Mukherjee
Feb 24, 2001·Annals of the New York Academy of Sciences·Z ZhangA B Mukherjee
Feb 24, 2001·Annals of the New York Academy of Sciences·G Singh, S L Katyal
Feb 24, 2001·Annals of the New York Academy of Sciences·T P Fleming, M A Watson
Feb 24, 2001·Annals of the New York Academy of Sciences·G C KunduA B Mukherjee
Feb 24, 2001·Annals of the New York Academy of Sciences·L Miele
Feb 24, 2001·Annals of the New York Academy of Sciences·B ChowdhuryA B Mukherjee
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Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yukiko Hayashi
Mar 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S D ReynoldsB R Stripp

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