Recombinant interferon-gamma applied to the brain ventricular system protects rats against pseudorabies

Journal of Neuroimmunology
V E SchijnsM C Horzinek

Abstract

We examined the prophylactic efficacy of recombinant rat interferon-gamma (IFN-gamma) administered directly into the brain ventricular system or via the intraperitoneal (i.p.) route against central and peripheral pseudorabies virus (PRV) infection. Intraperitoneally given IFN-gamma completely protected rats against a lethal i.p. PRV infection. The same regimen showed no protective effect against lethal intracerebroventricular (i.c.v.) PRV challenge even if IFN-gamma was given in high concentrations. When given via the i.c.v. route, IFN-gamma protected rats against lethal i.c.v. infection and also evoked partial protection with extended survival times of i.p. infected rats. Our results demonstrate an IFN-gamma-mediated antiviral effect in the central nervous system.

References

Dec 1, 1977·Cellular Immunology·I Gresser
Jun 1, 1986·The Journal of General Virology·P H van der MeideH Schellekens
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A Nathanson, L L Chun
Dec 1, 1988·Current Opinion in Immunology·R Dijkmans, A Billiau
Jan 1, 1981·Archives of Virology·A Billiau
Nov 19, 1981·The New England Journal of Medicine·H Prange, H Wismann
Jan 12, 1984·The New England Journal of Medicine·J S MoraT L Munsat
Jan 22, 1983·British Medical Journal·H SmedleyT Wheeler
Jan 1, 1980·The Journal of General Virology·H SchellekensW Weimar

❮ Previous
Next ❯

Citations

Jan 16, 2003·Physiology & Behavior·Faridis SerranoJ Patrick Card
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.