PMID: 2504273Aug 1, 1989Paper

Recombinant interferon-gamma induces HLA-DR expression on human corneal epithelial and endothelial cells in vitro: a preliminary report

The British Journal of Ophthalmology
A M el-AsrarL Missotten

Abstract

The effect of interferon-gamma on the expression in situ of major histocompatibility complex (MHC) products in human corneas was studied in vitro. Incubation for four days with 5 or 50 mg/l of Escherichia coli-derived recombinant human interferon-gamma resulted in the appearance de novo of MHC class II or HLA-DR antigens on variable numbers of corneal epithelial cells as well as on corneal endothelium, whereas it had no effect on the expression of MHC class I or HLA-ABC antigens. These results may help to explain the mechanism underlying the expression of HLA-DR antigens on corneal and limbal epithelium in various inflammatory eye diseases.

References

Apr 1, 1989·The British Journal of Ophthalmology·A M el-AsrarV Desmet
Dec 1, 1988·Documenta Ophthalmologica. Advances in Ophthalmology·A M abu el-AsrarV Desmet
Dec 15, 1984·American Journal of Ophthalmology·P A TreselerF Sanfilippo
Nov 1, 1982·American Journal of Ophthalmology·G N Foulks, F Sanfilippo
Jun 1, 1982·Ophthalmology·T E GilletteJ V Greiner

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Citations

Jul 1, 1991·Immunology Letters·D G Prendergast, D L Easty
Dec 5, 1998·Transplantation Proceedings·N MoritaK Tsuji
Jan 1, 1994·Eye·L Missotten
Oct 17, 1998·Eye·A M Abu el-AsrarV Desmet
Jul 1, 1993·The British Journal of Ophthalmology·G T FahyD L Easty
Mar 14, 1998·The British Journal of Ophthalmology·A M Abu el-AsrarV Desmet
Feb 1, 1996·American Journal of Ophthalmology·A M el-AsrarV Desmet
Jul 15, 1998·Current Eye Research·N ArdjomandH Radner
Jul 1, 1991·Tissue Antigens·N T YoungC Darke
Sep 1, 1991·Tissue Antigens·A N WiltonD W Cooper
Feb 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D G Doherty, P T Donaldson
Jun 1, 1996·Current Eye Research·V M BorderieB Y Delbosc

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