PMID: 2497199Feb 1, 1989Paper

Recombinant interferon-gamma inhibits cell invasion by Eimeria tenella

Journal of Interferon Research
M Kogut, C Lange

Abstract

Treatment of primary chicken kidney (CK) cultures with supernatants from concanavalin A-treated Eimeria tenella-immune avian splenic T cells significantly inhibited the invasion of the cells by sporozoites of E. tenella. Biochemical evaluation of this T-cell factor is consistent with the idea that this anti-Eimeria activity in the avian lymphokines is due to interferon-gamma (IFN-gamma). We then studied the effect of recombinant bovine and human IFN-gamma on the invasion of sporozoites of E. tenella in cultures of bovine and human cell lines, respectively. The initial infection of either the Madin-Darby bovine kidney cell line (MDBK) or the human larynx epidermoid carcinoma cell line (HEp-2) by the obligate intracellular protozoan parasite E. tenella was inhibited following a 24-h pretreatment with recombinant bovine or human IFN-gamma, respectively. The IFN-gamma-mediated inhibition was dose-dependent for both cell lines. Incubation of sporozoites of E. tenella with IFN-gamma alone before infection had no detectable inhibitory effect on cell invasion of either cell line by the parasite. In addition, the establishment of the antiinfective cellular state by IFN-gamma required at least a 16- to 24-h preincubation for significant ...Continue Reading

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Citations

Nov 1, 1995·International Journal for Parasitology·K S OvingtonE A Kerr
Aug 1, 2000·Avian Pathology : Journal of the W.V.P.A·L RothwellP Kaiser
Oct 1, 2000·Avian Pathology : Journal of the W.V.P.A·M H Kogut
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Jun 30, 2009·Veterinary Parasitology·Anja TaubertCarlos Hermosilla
Oct 25, 2008·Veterinary Immunology and Immunopathology·Anja TaubertHorst Zahner
Feb 7, 2014·Annual Review of Immunology·Sarah K Browne
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Jun 6, 2014·Expert Review of Clinical Immunology·Anthony Meager, Meenu Wadhwa
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Dec 12, 2019·Frontiers in Immunology·Woo H KimHyun S Lillehoj

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