Recombinant mouse interferon-gamma is not chemotactic for macrophages or neutrophils

Journal of Interferon Research
B P CanonoP A Campbell

Abstract

Recent evidence implicates interferon-gamma (IFN-gamma) in resistance to infection with the facultative intracellular bacterium, Listeria monocytogenes. Reports showing that inflammatory macrophages and neutrophils are highly bactericidal for listeria suggest that IFN-gamma might act by directly or indirectly causing recruitment of these cells. The purpose of the experiments described here was to test whether recombinant mouse IFN-gamma is chemotactic for macrophages or neutrophils in vivo or in vitro. In vivo experiments showed rIFN-gamma to have no ability to cause recruitment of inflammatory neutrophils or macrophages into the peritoneal cavities of mice. When tested in vitro, rIFN-gamma also did not induce migration of inflammatory neutrophils or macrophages through cellulose nitrate filters in a chemotaxis assay. The data indicate that rIFN-gamma has no direct or indirect chemotactic activity in vivo or in vitro for mouse macrophages or neutrophils.

References

Mar 1, 1986·Cellular Immunology·M J SteinbeckM L Kaeberle
Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Oct 1, 1984·European Journal of Immunology·A F KiderlenM L Lohmann-Matthes

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Citations

Oct 4, 2008·Developmental and Comparative Immunology·Leon Grayfer, Miodrag Belosevic
Apr 21, 2004·Immunology·Terri N Ellis, Blaine L Beaman
Nov 6, 2007·European Journal of Immunology·Waldiceu A VerriFernando Q Cunha
Jan 1, 1992·Cellular Immunology·A A HiesterP A Campbell
Mar 10, 2009·Cytokine & Growth Factor Reviews·Alfons Billiau, Patrick Matthys

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