Recombinant mouse interferon-gamma regulation of antibody production.

Infection and Immunity
H M Johnson, B A Torres

Abstract

Interferon-gamma produced in monkey cells by transfection with mouse interferon-gamma cDNA suppressed the mouse in vitro antibody response in a manner similar to that of natural mouse interferon-gamma. Significant suppression was obtained with as little as 1 U of interferon. Recombinant human interferon-gamma produced by cloning in a similar fashion was not suppressive. Both the suppressive and the antiviral activities of recombinant interferon-gamma were neutralized by antibodies to mouse natural interferon-gamma. Thus, interferon-gamma was responsible for the immunosuppression. At the cellular level, the recombinant interferon-gamma was capable of activating macrophages to suppress antibody production. The data provide clear-cut evidence that interferon-gamma plays an important role in regulation of immunological processes.

References

Jul 15, 1980·Cellular Immunology·L C OsborneH M Johnson
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Aug 1, 1980·Infection and Immunity·H M Johnson, J E Blalock
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim

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Citations

Jan 1, 1988·Journal of Veterinary Internal Medicine·K L Jacobsen, G A Rockwood
Jun 1, 1987·Journal of Interferon Research·S Fernandez-CasteloV E Nahmod
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·John S TregoningPeter J Openshaw
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld
Feb 1, 1990·Infection and Immunity·M J OdeanA G Johnson
Jul 1, 1985·Infection and Immunity·F R VogelH Friedman
Aug 1, 1989·Seminars in Arthritis and Rheumatism·D A Watrous, B S Andrews
Nov 1, 1987·Cellular Immunology·P K AroraE E Hanna

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