Recombinant murine interferon-gamma inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A VigneryM H Shepard

Abstract

Osteoclasts are multinucleated cells that originate from the fusion of mononuclear precursors and are responsible for bone resorption. Indirect evidence from in vitro studies suggests that IFN-gamma and TNF-alpha inhibit and stimulate bone resorption, respectively, but contradictory results have emerged from the literature regarding the effects of IFN-gamma on macrophage multinucleation. Using highly sensitive model systems, the present work demonstrates that, in mice, rMuIFN-gamma inhibits the fusion of alveolar macrophages in vitro but augments the number of osteoclastlike cells on implanted syngeneic bone particles in vivo. Although rMuTNF-alpha fails to stimulate macrophage multinucleation in either system, treatment of implanted animals with rMuIFN-gamma appears to limit the inflammatory reaction and favor tissue repair.

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Citations

Apr 1, 1993·Journal of Biomedical Materials Research·K Gomi, J E Davies
Jan 1, 1994·Journal of Biomedical Materials Research·J D de BruijnC A van Blitterswijk
Apr 9, 2005·Trends in Cell Biology·Agnès Vignery
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Aug 7, 2008·BMB Reports·Seoung-Hoon LeeJoseph Lorenzo
Dec 6, 2005·Médecine sciences : M/S·Agnès Vignery

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