Recombinant Mycobacterium bovis BCG for immunotherapy in nonmuscle invasive bladder cancer

Applied Microbiology and Biotechnology
K R BegniniF K Seixas

Abstract

In the past three decades, intravesical instillation of Mycobacterium bovis bacille Calmette-Guérin (BCG) has been used for treating bladder cancer and it still remains at the forefront of immunotherapy for cancer patients. Although BCG-based therapy is the most effective intravesical therapy for this kind of tumor and represents the only agent known to reduce progression into muscle invasive bladder cancer, BCG is ineffective in approximately 30-40 % of cases and disease recurs in up to 50 % of patients. Since that BCG is considered an effective vehicle for delivery of antigens due to its unique characteristics, the genetic manipulation of these mycobacteria has been appealing in the search for less toxic and more potent therapeutic agents for bladder cancer immunotherapy. Herein, we discuss current advances in recombinant BCG construction, research, concerns, and future directions to promote the development of this promising immunotherapeutic approach for bladder cancer.

References

Aug 1, 1991·Molecular Microbiology·P M EnglandJ McFadden
Dec 1, 1990·Infection and Immunity·K MatsuoT Yamada
Apr 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·M H LeeG F Hatfull
Jun 6, 1991·Nature·C K StoverG F Hatfull
Feb 1, 1990·Journal of Bacteriology·R N HussonR A Young
Apr 1, 1990·Immunology Today·S H Kaufmann
Oct 6, 1989·Cell·R A Young, T J Elliott
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S B SnapperW R Jacobs
Feb 1, 1988·The Journal of Urology·H RübbenG Giani
Oct 1, 1974·Annals of Surgery·D L MortonF C Sparks
Sep 1, 1995·The Journal of Infectious Diseases·G J FennellyB R Bloom
Dec 1, 1993·Molecular Microbiology·O A DellagostinJ McFadden
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N D ConnellD G Russell
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·P J MurrayR A Young
Mar 1, 1996·Nature Medicine·I GuleriaB R Bloom
Jul 1, 1997·The Journal of Urology·M S CooksonW R Fair
Apr 9, 1999·The Journal of Clinical Investigation·J WangZ Xing
May 21, 1999·Lancet·A B AlexandroffK James
Sep 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T L Ratliff
Oct 29, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S AtkinsonH M Dockrell
May 8, 2001·International Journal of Cancer. Journal International Du Cancer·S BrandauA Böhle

❮ Previous
Next ❯

Citations

Sep 15, 2015·Expert Review of Vaccines·Tony W NgSteven A Porcelli
Dec 21, 2017·Frontiers in Pharmacology·Natalia V SegattoTiago Collares
May 29, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jennifer ZieglerPamela Orr
Dec 7, 2016·Pharmacological Reports : PR·Tatiana B FogaçaTiago Collares
Aug 14, 2019·Applied Microbiology and Biotechnology·Martha Lucia Ruiz BenitezFabiana Kömmling Seixas
Jul 12, 2019·Frontiers in Oncology·Gabriela Klein CoutoTiago Collares
Aug 28, 2020·Frontiers in Chemistry·Katia PaneMonica Franzese
Jan 19, 2021·Case Reports in Infectious Diseases·Harpreet S GillPinky Jha
Jul 6, 2021·Expert Review of Vaccines·Lazaro M Marques-NetoLuciana C C Leite

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.