PMID: 9430249Jan 16, 1998Paper

Recombinant Mycobacterium bovis BCG producing the N-terminal half of SIVmac251 Env antigen induces neutralizing antibodies and cytotoxic T lymphocyte responses in mice and guinea pigs

AIDS Research and Human Retroviruses
E M LimN Winter

Abstract

Recombinant Mycobacterium bovis bacillus Calmette-Guérin (rBCG) represents a good candidate for the development of vaccines against AIDS. Several HIV or SIV genes including nef, gag, and env have already been expressed by rBCG strains and shown to induce strong humoral and cellular immune responses in experimental animals. Because a broad immune response directed to multiple HIV/SIV antigens is highly desirable in order to develop effective vaccines, we have also investigated the immune response induced by an rBCG strain expressing a large N-terminal portion of the SIVmac251 Env gp110-encoding gene. The rBCG(SIVmac251Env) strain obtained was able to induce strong CTL responses in mice as well as humoral immune responses in mice and guinea pigs immunized by parenteral routes. The anti-gp110 IgGs produced were able to neutralize in vitro growth of virulent SIVmac251 field isolates. Moreover, guinea pigs immunized by the oral route produced significant levels of anti-gp110 IgAs in the feces, demonstrating that rBCG is able to induce local humoral immunity in the intestinal mucosa. These data provide further evidence of the utility of BCG as a candidate vaccine vector against AIDS.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K JavaherianD P Bolognesi
Jun 6, 1991·Nature·C K StoverG F Hatfull
Apr 28, 1990·Lancet·P E Fine, L C Rodrigues
Jan 1, 1988·Journal of Biological Standardization·M GheorghiuC Fillastre
Apr 1, 1995·AIDS Research and Human Retroviruses·S MatsumiK Takatsuki
Jan 1, 1993·AIDS·A Venet, B D Walker
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N D ConnellD G Russell
Jan 1, 1997·Immunology Today·J L HeeneyS Zolla-Pazner

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Citations

Jul 18, 2001·Vaccine·N Ohara, T Yamada
Feb 5, 2000·AIDS Research and Human Retroviruses·L A FalkS Yamazaki
Mar 1, 2003·Journal of Virology·Sang-Moo Kang, Richard W Compans
Sep 6, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I P Nascimento, L C C Leite
Dec 23, 2006·Expert Review of Vaccines·Joan JosephJosep Maria Gatell
Mar 15, 2003·International Journal of Medical Microbiology : IJMM·Guido DietrichJürgen Hess
Jun 9, 2007·Journal of Immune Based Therapies and Vaccines·B AnuradhaValluri Vijaya Lakshmi
Aug 30, 2000·Tropical Medicine & International Health : TM & IH·F GotchJ Whitworth
May 1, 2015·Clinical and Vaccine Immunology : CVI·Bryan E HartRichard Frothingham
Oct 10, 2018·Expert Review of Vaccines·Athina KilpeläinenJoan Joseph Munne

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