Recombinant organisms for production of industrial products

Bioengineered Bugs
Jose-Luis Adrio, Arnold L Demain

Abstract

A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products.

References

Dec 1, 1979·Applied and Environmental Microbiology·S KomatsubaraI Chibata
Apr 1, 1991·Journal of Industrial Microbiology·W R StrohlR H Woodman
Feb 1, 1992·Letters in Applied Microbiology·Y H TsengC C Chen
Sep 1, 1992·Journal of Bacteriology·H M KieserD A Hopwood
Jan 1, 1990·Annals of the New York Academy of Sciences·K BackmanR Hatch
Oct 1, 1986·Applied and Environmental Microbiology·G P O'NeillR C Miller
Oct 1, 1987·Applied and Environmental Microbiology·L O IngramJ F Preston
Jan 1, 1986·Gene·F MondouD Kluepfel
Jun 1, 1983·Applied and Environmental Microbiology·D D RyuH S Pai
Sep 1, 1995·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·E Vasquez
Jul 1, 1995·Applied Microbiology and Biotechnology·G E ColónG Stephanopoulos
Jul 29, 1994·Journal of Biotechnology·N SakuraiT Tosa
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S DonadioL Katz
Feb 1, 1997·Antonie van Leeuwenhoek·R H BaltzP J Solenberg
Mar 15, 1997·Nucleic Acids Research·H Zhao, F H Arnold
May 1, 1997·Nature Biotechnology·L P Wackett
Nov 14, 1997·Trends in Genetics : TIG·M A HuynenP Bork
Jan 13, 1998·Current Opinion in Biotechnology·P A PattenW P Stemmer
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·B Van den BurgV G Eijsink
Mar 1, 1996·Nature Biotechnology·A CrameriW P Stemmer

❮ Previous
Next ❯

Citations

Dec 13, 2012·Microbial Cell Factories·Sang Yup LeeAntonio Villaverde
Feb 11, 2016·Microbial Cell Factories·Laura Sanchez-GarciaAntonio Villaverde
Sep 21, 2011·Trends in Biotechnology·Roberto MazzoliEnrica Pessione
Jan 18, 2014·Journal of Structural Biology·Zhuoxin YuBarbara Brodsky
Apr 11, 2014·Bioengineered·John A M RamshawGeoff J Dumsday
May 27, 2014·Frontiers in Microbiology·Germán L Rosano, Eduardo A Ceccarelli
Nov 22, 2014·Journal of Industrial Microbiology & Biotechnology·Jie Sun, Hal S Alper
Nov 30, 2014·Applied Microbiology and Biotechnology·Andrea M OchsnerJulia A Vorholt
Aug 30, 2014·Pharmaceutical Research·Thiago CaonJoseph A Nicolazzo
Aug 21, 2016·Analytica Chimica Acta·Giorgio Gianini MorbioliEmanuel Carrilho
Apr 10, 2017·3 Biotech·Rajendra SinghPraveen Kumar Mehta
Jul 19, 2018·Antibiotics·Daniela de Araújo Viana MarquesAna Lúcia Figueiredo Porto
Apr 11, 2020·Critical Reviews in Food Science and Nutrition·Paul Hanlon, Vincent Sewalt
Aug 5, 2020·Molecular Biotechnology·Amjad Hayat KhanRahmah Noordin
Dec 22, 2017·Biopolymers·Marco CavacoVera Neves
Jan 29, 2019·Frontiers in Bioengineering and Biotechnology·Larissa Pereira BrumanoAdalberto Pessoa Junior
Mar 25, 2019·Scientific Reports·Anssi RantasaloDominik Mojzita
Aug 25, 2018·World Journal of Microbiology & Biotechnology·Sayak MitraBiswanath Mahanty
Oct 9, 2020·BMC Veterinary Research·Manoel Neres Santos JuniorLucas Miranda Marques
Jan 22, 2021·Synthetic and Systems Biotechnology·Dongwon ParkBlaine A Pfeifer
Feb 8, 2020·Journal of Microbiological Methods·Anshula SharmaKhalid Rehman Hakeem
Nov 23, 2016·Enzyme and Microbial Technology·Somaieh RahnamaRahman Emamzadeh
Jun 10, 2021·Pediatric Blood & Cancer·Luke MaeseRachel E Rau
Dec 15, 2020·Current Opinion in Biotechnology·Shanshan LiWeishan Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.