Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin 1

Veterinary Immunology and Immunopathology
B CharleyL Lavenant

Abstract

The effect of recombinant porcine interferon-gamma (rPoIFN gamma) on in vitro production of interleukin 1 (IL-1) by porcine blood monocytes was studied. Three-day-old cultures of porcine adherent blood mononuclear cells were treated by doses of rPoIFN gamma for 3 or 6 days before lipopolysaccharide (LPS)-induction. While rPoIFN gamma alone had no effect, a combined treatment by rPoIFN gamma and LPS enhanced the IL-1 secretory potential of adherent mononuclear cells and, to a lesser extent, the level of cell-associated IL-1. The IL-1 activity was neutralized by anti porcine IL-1 alpha and beta antisera. These results demonstrate that rPoIFN gamma has immunomodulatory effects in vitro on porcine monokine production.

References

May 1, 1987·Veterinary Immunology and Immunopathology·S W Russell, J L Pace
May 1, 1987·Antiviral Research·H B OhmannL A Babiuk
Sep 1, 1988·Veterinary Immunology and Immunopathology·B CharleyS Martinod
Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

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Citations

Apr 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R ScamurraM P Murtaugh
Jan 23, 2009·Veterinary Immunology and Immunopathology·Wasin Charerntantanakul
Apr 9, 2014·Developmental and Comparative Immunology·K H MairF Meurens
Jan 1, 1991·Journal of Dairy Science·F Blecha
Jan 15, 2011·Journal of Leukocyte Biology·Lynsey FairbairnDavid A Hume

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