Abstract
Two experiments (EXP) were conducted to test the hypothesis that porcine leptin affects GH, insulin-like growth factor-I (IGF-I), insulin, thyroxine (T4) secretion, and feed intake. In EXP I, prepuberal gilts received intracerebroventricular (i.c.v.) leptin injections. Blood was collected every 15 min for 4 hr before and 3 hr after i.c.v. injections of 0.9% saline (S; n = 3), 10 micrograms (n = 4), 50 micrograms (n = 4), or 100 micrograms (n = 4) of leptin in S. Pigs were fed each day at 0800 and 1700 hr over a 2-wk period before the EXP. On the day of the EXP, pigs were fed at 0800 hr and blood sampling started at 0900 h. After the last sample was collected, feeders were placed in all pens. Feed intake was monitored at 4, 20, and 44 hr after feed presentation. In EXP II, pituitary cells from prepuberal gilts were studied in primary culture to determine if leptin affects GH secretion at the level of the pituitary. On Day 4 of culture, 10(5) cells/well were challenged with 10(-12), 10(-10), 10(-8), or 10(-6) M [Ala15]-h growth hormone-releasing factor-(1-29)NH2 (GRF), 10(-14), 10(-13), 10(-12), 10(-11), 10(-10), 10(-9), 10(-8), 10(-7), or 10(-6) M leptin individually or in combinations with 10(-8) and 10(-6) M GRF. Secreted GH w...Continue Reading
References
Jun 1, 1991·Endocrinology·J C Painson, G S Tannenbaum
Oct 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·C R BarbT F Mowles
Jan 1, 1991·Domestic Animal Endocrinology·C R BarbJ L Sartin
May 1, 1990·Endocrinology·V RettoriS M McCann
Feb 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·M J EstienneC E Estienne
Jan 1, 1985·Endocrine Reviews·J O JanssonO Isaksson
Oct 1, 1987·Domestic Animal Endocrinology·P DubreuilJ Morisset
Jan 1, 1982·Journal of Reproduction and Fertility·C R BarbT E Kiser
Apr 1, 1980·The Journal of Clinical Endocrinology and Metabolism·K C CopelandJ J Van Wyk
Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Oct 12, 1995·Nature·T W StephensA Kriauciunas
Jul 28, 1995·Science·L A CampfieldP Burn
Apr 1, 1993·Neuroendocrinology·K OkadaI Wakabayashi
Mar 1, 1994·Neuroendocrinology·L S LeshinR R Kraeling
Dec 29, 1995·Cell·L A TartagliaR I Tepper
Dec 1, 1995·Biology of Reproduction·N C WhitleyG B Rampacek
Jun 3, 1996·FEBS Letters·J G MercerP Trayhurn
Jul 18, 1996·Nature·R S AhimaJ S Flier
Nov 1, 1996·Diabetes·J F CaroR V Considine
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L A CampfieldP Burn
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Mar 1, 1997·Domestic Animal Endocrinology·C J DyerD H Keisler
Jun 24, 2000·Journal of Reproduction and Fertility·J Bakker, M J Baum
Citations
May 24, 2005·Brain Research·Sami DridiJohan Buyse
Jan 21, 2004·Domestic Animal Endocrinology·Timothy G Ramsay
Mar 24, 2004·Domestic Animal Endocrinology·M R GarciaG L Williams
Mar 24, 2004·Domestic Animal Endocrinology·C R BarbR R Kraeling
May 26, 2004·Domestic Animal Endocrinology·S CassyM Taouis
Mar 7, 2003·General and Comparative Endocrinology·Mare LõhmusBengt Silverin
Jan 7, 1999·Physiology & Behavior·M G HulseyC A Baile
Jun 28, 2000·Physiology & Behavior·D M DenbowC Ashwell
May 8, 2000·Theriogenology·B R LackeyD M Henricks
Jan 22, 2003·Animal Reproduction Science·M J EstienneJ W Knight
Aug 30, 2000·Domestic Animal Endocrinology·J LinG B Rampacek
Dec 19, 2000·Domestic Animal Endocrinology·M J EstienneM J Azain
Feb 13, 2001·Domestic Animal Endocrinology·C R BarbG B Rampacek
Apr 20, 2001·Domestic Animal Endocrinology·C D McMahonH A Tucker
Mar 2, 2002·Domestic Animal Endocrinology·C R BarbK L Houseknecht
Mar 20, 2002·Domestic Animal Endocrinology·C S Whisnant, R J Harrell
Mar 20, 2002·Domestic Animal Endocrinology·C D MorrisonD H Keisler
Mar 2, 2002·Domestic Animal Endocrinology·K L Ingvartsen, Y R Boisclair
Nov 27, 2002·Domestic Animal Endocrinology·C D MorrisonD H Keisler
Feb 15, 2003·Domestic Animal Endocrinology·J LinG B Rampacek
Dec 23, 1998·Domestic Animal Endocrinology·K L Houseknecht, C P Portocarrero
Apr 29, 1999·Domestic Animal Endocrinology·H QianC A Baile
Sep 14, 1999·Domestic Animal Endocrinology·C M AshwellR Vasilatos-Younken
Aug 24, 1999·Alcohol·W E Lands
Sep 25, 2003·The Journal of Nutritional Biochemistry·Kolapo M AjuwonMichael E Spurlock
Sep 5, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Christina M Evock-CloverJohn P McMurtry
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Jul 11, 2008·The British Journal of Nutrition·Georgios A PapadopoulosGeert P J Janssens
Jan 1, 2008·Animal : an International Journal of Animal Bioscience·A MoriseI Le Huërou-Luron
Feb 1, 2009·Animal : an International Journal of Animal Bioscience·H R Martínez-RamírezC F M de Lange
Sep 5, 2001·Animal Genetics·Y M KennesM F Palin
Sep 1, 1999·Clinical Endocrinology·J Lado-AbealR L Norman
Oct 2, 2002·Clinical Endocrinology·Massimo GiustiFrancesco Minuto
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·I J ClarkeJ W Goding
Mar 21, 2006·British Poultry Science·Z D ShiM Taouis
Feb 2, 2000·Animal Biotechnology·K LeeC A Baile
Jan 4, 2005·Biology of the Neonate·J C LittenL Clarke
Nov 6, 2004·Neuroendocrinology·Aleksandra Glavaski-JoksimovicSrdija Jeftinija
Jun 2, 2007·Neuroendocrinology·Colin G ScanesLloyd L Anderson
Sep 27, 2007·Neonatology·J C LittenL Clarke
Jun 28, 2013·Journal of Animal Science and Biotechnology·Yingdong NiRuqian Zhao
Mar 27, 2012·PloS One·Luc te Marvelde, Marcel E Visser
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M MitchellR J Norman
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·C Richard BarbGary J Hausman
Feb 9, 2016·General and Comparative Endocrinology·Eugene T WonRussell J Borski
Dec 24, 2015·Animal : an International Journal of Animal Bioscience·F HernándezJ Madrid
Aug 6, 2008·Domestic Animal Endocrinology·Hideki OgasawaraTakahiro Yamaguchi
Mar 28, 2008·Domestic Animal Endocrinology·Hideki OgasawaraTakahiro Yamaguchi
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·C R BarbC A Lents
Aug 3, 2012·Journal of Animal Physiology and Animal Nutrition·P LiuR Zhao