PMID: 9437587Jan 23, 1998Paper

Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine

Domestic Animal Endocrinology
C R BarbT G Ramsay

Abstract

Two experiments (EXP) were conducted to test the hypothesis that porcine leptin affects GH, insulin-like growth factor-I (IGF-I), insulin, thyroxine (T4) secretion, and feed intake. In EXP I, prepuberal gilts received intracerebroventricular (i.c.v.) leptin injections. Blood was collected every 15 min for 4 hr before and 3 hr after i.c.v. injections of 0.9% saline (S; n = 3), 10 micrograms (n = 4), 50 micrograms (n = 4), or 100 micrograms (n = 4) of leptin in S. Pigs were fed each day at 0800 and 1700 hr over a 2-wk period before the EXP. On the day of the EXP, pigs were fed at 0800 hr and blood sampling started at 0900 h. After the last sample was collected, feeders were placed in all pens. Feed intake was monitored at 4, 20, and 44 hr after feed presentation. In EXP II, pituitary cells from prepuberal gilts were studied in primary culture to determine if leptin affects GH secretion at the level of the pituitary. On Day 4 of culture, 10(5) cells/well were challenged with 10(-12), 10(-10), 10(-8), or 10(-6) M [Ala15]-h growth hormone-releasing factor-(1-29)NH2 (GRF), 10(-14), 10(-13), 10(-12), 10(-11), 10(-10), 10(-9), 10(-8), 10(-7), or 10(-6) M leptin individually or in combinations with 10(-8) and 10(-6) M GRF. Secreted GH w...Continue Reading

References

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Citations

May 24, 2005·Brain Research·Sami DridiJohan Buyse
Jan 21, 2004·Domestic Animal Endocrinology·Timothy G Ramsay
May 26, 2004·Domestic Animal Endocrinology·S CassyM Taouis
Mar 7, 2003·General and Comparative Endocrinology·Mare LõhmusBengt Silverin
Jun 28, 2000·Physiology & Behavior·D M DenbowC Ashwell
Jan 22, 2003·Animal Reproduction Science·M J EstienneJ W Knight
Apr 20, 2001·Domestic Animal Endocrinology·C D McMahonH A Tucker
Mar 2, 2002·Domestic Animal Endocrinology·C R BarbK L Houseknecht
Dec 23, 1998·Domestic Animal Endocrinology·K L Houseknecht, C P Portocarrero
Sep 14, 1999·Domestic Animal Endocrinology·C M AshwellR Vasilatos-Younken
Sep 25, 2003·The Journal of Nutritional Biochemistry·Kolapo M AjuwonMichael E Spurlock
Sep 5, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Christina M Evock-CloverJohn P McMurtry
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Jan 1, 2008·Animal : an International Journal of Animal Bioscience·A MoriseI Le Huërou-Luron
Feb 1, 2009·Animal : an International Journal of Animal Bioscience·H R Martínez-RamírezC F M de Lange
Jan 12, 2001·Clinical and Experimental Pharmacology & Physiology·I J ClarkeJ W Goding
Nov 6, 2004·Neuroendocrinology·Aleksandra Glavaski-JoksimovicSrdija Jeftinija
Mar 27, 2012·PloS One·Luc te Marvelde, Marcel E Visser
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M MitchellR J Norman
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·C Richard BarbGary J Hausman
Dec 24, 2015·Animal : an International Journal of Animal Bioscience·F HernándezJ Madrid
Aug 6, 2008·Domestic Animal Endocrinology·Hideki OgasawaraTakahiro Yamaguchi
Mar 28, 2008·Domestic Animal Endocrinology·Hideki OgasawaraTakahiro Yamaguchi
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·C R BarbC A Lents

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