Recombinant PTH therapy for severe hypoparathyroidism after kidney transplantation in pre-transplant parathyroidectomized patients: review of the literature and a case report

Clinical Transplantation
Tammy HodAnil Chandraker

Abstract

Although transient hypocalcemia following kidney transplantation can occur, severe refractory hypocalcemia is uncommon. We report a case of a 31-yr-old highly sensitized man with end-stage renal disease caused by reflux nephropathy, who received an expanded criteria deceased donor kidney transplant. The post-transplant course was significant for profound hypocalcemia despite treatment with large doses of calcium and vitamin D, in the setting of severe hypoparathyroidism following a subtotal parathyroidectomy three yr prior to the transplant. His course was also complicated by suboptimal allograft function with significant new vascular changes seen in the allograft biopsy by seven wk post-transplant. Teriparatide (recombinant parathyroid hormone) injections were initiated (up to three times daily) with improvement in the vascular changes and a decrease in calcium phosphate calcification in biopsy, as well as reduction in hypercalciuria, restoration of calcium phosphate homeostasis and stabilization of allograft function. We describe six other cases of post-transplant hypoparathyroidism, with five of six having decreased allograft function and three of those five demonstrating significant accelerated vascular changes on biopsy. W...Continue Reading

References

Feb 1, 1979·The Surgical Clinics of North America·S A WellsR S Gray
Aug 3, 1991·BMJ : British Medical Journal·C J FergusonJ R Salaman
Aug 28, 1996·JAMA : the Journal of the American Medical Association·K K WinerG B Cutler
Dec 17, 2003·Kidney International·Bryan KestenbaumCatherine O Stehman-Breen
May 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pieter EvenepoelYves Vanrenterghem
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wilfried GwinnerAnke Schwarz
Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·N M TorregrosaP Parrilla
Oct 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anke SchwarzHermann Haller
Mar 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pieter EvenepoelYves Vanrenterghem
Nov 16, 2007·The New England Journal of Medicine·Kenneth G SaagRobert Marcus
Jun 27, 2008·Annals of Surgery·Frédéric TriponezPieter Evenepoel
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D CejkaM Haas
Jul 1, 2010·Kidney & Blood Pressure Research·Daniel CejkaMartin Haas
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S M FlechnerMira Milas
Nov 22, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Catherine MadorinAlfio Ferlito
Nov 28, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L RejnmarkL Mosekilde

❮ Previous
Next ❯

Citations

Jul 9, 2016·Vascular Pharmacology·Cristina Vassalle, Annamaria Mazzone
Jul 27, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ya-li YangWan-qing Liao
Nov 6, 2018·Current Osteoporosis Reports·Ariella M Altman, Stuart M Sprague
Feb 13, 2018·Artificial Organs·Gaetano La Manna
Oct 15, 2021·Hormones : International Journal of Endocrinology and Metabolism·Beatriz Ugalde-AbiegaIsabel Huguet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nefrología : publicación oficial de la Sociedad Española Nefrologia
Luis LeónDomingo Casadei
Transplant International : Official Journal of the European Society for Organ Transplantation
Paolo CartaEnrico Eugenio Minetti
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Elisabeth OschatzMartin Haas
© 2021 Meta ULC. All rights reserved