PMID: 9557743Apr 29, 1998Paper

Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees

Journal of Virology
S S WhiteheadB R Murphy

Abstract

A set of five missense mutations previously identified by nucleotide sequence analysis of subgroup A cold-passaged (cp) respiratory syncytial virus (RSV) has been introduced into a recombinant wild-type strain of RSV. This recombinant virus, designated rA2cp, appears to replicate less efficiently in the upper and lower respiratory tracts of seronegative chimpanzees than either biologically derived or recombinant wild-type RSV. Infection with rA2cp also resulted in significantly less rhinorrhea and cough than infection with wild-type RSV. These findings confirm the role of the cp mutations in attenuation of RSV and identify their usefulness for inclusion in future live attenuated recombinant RSV vaccine candidates.

References

Mar 1, 1989·Journal of Virology·G D WestropG C Schild

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Citations

Apr 8, 2011·Journal of Virology·Kate L StokesMartin L Moore
Jun 19, 2019·Open Forum Infectious Diseases·Coleen K CunninghamUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2012 Study Team
Sep 27, 2003·Journal of Virology·Kirsten M SpannMichael N Teng
Oct 5, 2013·The Journal of General Virology·Heather A LawlorRoderick S Tang
Feb 26, 2020·Pathogens·Daniela Ogonczyk MakowskaGuy Boivin
Oct 22, 2002·The Journal of General Virology·Gabriele NeumannYoshihiro Kawaoka
Dec 22, 2006·Expert Review of Vaccines·Ursula J BuchholzPeter L Collins
Feb 11, 2015·The Journal of General Virology·J RenX Bao
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kerrianne N HuynhEuan R Tovey
Jan 5, 2012·The Journal of Biological Chemistry·Melanie DochowRichard K Plemper
Mar 7, 2018·The Journal of Infectious Diseases·Ursula J BuchholzUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1114 Study Team
Apr 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Wendy K JoMartin Ludlow
Mar 15, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ultan F Power

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