PMID: 2125249Sep 1, 1990Paper

Recombinant t-PA and platelet activity

Cleveland Clinic Journal of Medicine
R C Becker

Abstract

Platelet-rich coronary arterial occlusions are relatively resistant to thrombolysis with recombinant tissue-type plasminogen activator, or rt-PA, while erythrocyte-rich thrombi are lysed at low doses. The combined administration of rt-PA with a platelet antagonist enhances thrombolysis and can prevent reocclusion, which suggests that platelet activation predominates during thrombus formation and after thrombolysis. In addition to direct effects on platelet activity, rt-PA also acts indirectly through generation of plasmin, which degrades fibrin.

Citations

Sep 1, 1991·Progress in Cardiovascular Diseases·J HenkinH C Yang

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