Recombinant varicella vaccines induce neutralizing antibodies and cellular immune responses to SIV and reduce viral loads in immunized rhesus macaques.

Vaccine
Vicki L Traina-DorgeWayne Gray

Abstract

The development of an effective AIDS vaccine remains one of the highest priorities in HIV research. The live, attenuated varicella-zoster virus (VZV) Oka vaccine, safe and effective for prevention of chickenpox and zoster, also has potential as a recombinant vaccine against other pathogens, including human immunodeficiency virus (HIV). The simian varicella model, utilizing simian varicella virus (SVV), offers an approach to evaluate recombinant varicella vaccine candidates. Recombinant SVV (rSVV) vaccine viruses expressing simian immunodeficiency virus (SIV) env and gag antigens were constructed. The hypothesis tested was that a live, attenuated rSVV-SIV vaccine will induce immune responses against SIV in the rhesus macaques and provide protection against SIV challenge. The results demonstrated that rSVV-SIV vaccination induced low levels of neutralizing antibodies and cellular immune responses to SIV in immunized rhesus macaques and significantly reduced viral loads following intravenous challenge with pathogenic SIVmac251-CX-1.

References

Jan 8, 1999·Journal of Medical Primatology·W L GrayK F Soike
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Silvija I StapransMark B Feinberg
Sep 24, 2004·Reviews in Medical Virology·Wayne L Gray
Jun 17, 2006·The Journal of Infectious Diseases·Myron J LevinUNKNOWN Pediatric AIDS Clinical Trials Group 265 Team
Feb 15, 2008·The Journal of General Virology·Toby M WardWayne L Gray
May 6, 2010·The Journal of Infectious Diseases·Moeun SonAnne A Gershon

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Citations

Feb 13, 2013·The Journal of Experimental Medicine·Laura E McCoy, Robin A Weiss
Nov 9, 2018·Journal of Virology·Vicki Traina-DorgeRavi Mahalingam
Sep 12, 2020·Vaccines·Ziyu Wen, Caijun Sun
Aug 28, 2019·Current Immunology Reviews·Pamela A Kozlowski, Anna Aldovini

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