Recombinant versus urinary follicle-stimulating hormone in intrauterine insemination cycles: a prospective, randomized analysis of cost effectiveness

Fertility and Sterility
Sandro GerliGian Carlo Di Renzo

Abstract

To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles. Prospective, randomized trial. University Hospital, Perugia, and A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. IUI cycles were performed in 67 infertile patients. Protocols of ovarian stimulation with urinary FSH or recombinant FSH were randomly assigned, for a total of 138 cycles performed (67 and 71, respectively). Number of mature follicles, days of stimulation, number of ampules, and IU used per cycle, biochemical/clinical pregnancy rates and cost-effectiveness ratio. Follicular development, length of stimulation, pregnancy and delivery rates were not statistically different. Although in the urinary FSH group a significantly higher number of IU of gonadotropins were used (815.5 +/- 284.9 vs. 596.0 +/- 253.8), the cost per cycle remained significantly lower (220.73 +/- 94.72 vs. 318.50 +/- 125.21). The cost-effectiveness ratio was 1,848.61 euro in the urinary FSH group and 2,512.61 euro in the recombinant FSH group. Urinary FSH and recombinant FSH are both effective in ovarian stimulation in IUI cycles. The urinary preparation is more cost effective due to the difference of its cos...Continue Reading

References

Feb 1, 1996·Human Reproduction·J FarhiH S Jacobs
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Citations

Dec 17, 2009·Obstetrics and Gynecology International·Abdelrahman M Abdelkader, John Yeh
Feb 18, 2010·Biologics : Targets & Therapy·Ahmed Gibreel, Siladitya Bhattacharya
Mar 25, 2011·Fertility and Sterility·Roberto MatorrasJosé Ignácio Pijoan
Aug 25, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Matteo RuggeriAmerico Cicchetti
Nov 30, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Amir WiserTogas Tulandi
Jan 29, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sandro GerliGian Carlo Di Renzo
Nov 6, 2021·The Cochrane Database of Systematic Reviews·Astrid Ep CantineauBen J Cohlen

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