Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens

Human Vaccines & Immunotherapeutics
Anahita FathiMarylyn M Addo

Abstract

The devastating Ebola virus (EBOV) outbreak in West Africa in 2013-2016 has flagged the need for the timely development of vaccines for high-threat pathogens. To be better prepared for new epidemics, the WHO has compiled a list of priority pathogens that are likely to cause future outbreaks and for which R&D efforts are, therefore, paramount (R&D Blueprint: https://www.who.int/blueprint/priority-diseases/en/ ). To this end, the detailed characterization of vaccine platforms is needed. The vesicular stomatitis virus (VSV) has been established as a robust vaccine vector backbone for infectious diseases for well over a decade. The recent clinical trials testing the vaccine candidate VSV-EBOV against EBOV disease now have added a substantial amount of clinical data and suggest VSV to be an ideal vaccine vector candidate for outbreak pathogens. In this review, we discuss insights gained from the clinical VSV-EBOV vaccine trials as well as from animal studies investigating vaccine candidates for Blueprint pathogens.

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Citations

Jul 5, 2019·Science Translational Medicine·Natalie E DeanIra M Longini
Jul 1, 2020·Expert Opinion on Biological Therapy·Altar M MunisYasuhiro Takeuchi
Jan 18, 2019·Pathogens·Dylan M JohnsonIgor S Lukashevich
Dec 18, 2020·Nature Communications·Yfat Yahalom-RonenTomer Israely
Dec 11, 2021·Applied Microbiology and Biotechnology·Zrinka Matić, Maja Šantak

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Methods Mentioned

BETA
genetic modification

Clinical Trials Mentioned

NCT02923466
NCT02269423
NCT02280408
NCT02374385
NCT02283099
NCT02296983
NCT02718469
NCT02314923
NCT02287480
NCT02344407

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