Recombination and gene flux caused by gene conversion and crossing over in inversion heterokaryotypes.

Genetics
A NavarroAlfredo Ruiz

Abstract

A theoretical analysis of the effects of inversions on recombination and gene flux between arrangements caused by gene conversion and crossing over was carried out. Two different mathematical models of recombination were used: the Poisson model (without interference) and the Counting model (with interference). The main results are as follows. (1) Recombination and gene flux are highly site-dependent both inside and outside the inverted regions. (2) Crossing over overwhelms gene conversion as a cause of gene flux in large inversions, while conversion becomes relatively significant in short inversions and in regions around the breakpoints. (3) Under the Counting model the recombination rate between two markers depends strongly on the position of the markers along the inverted segment. Two equally spaced markers in the central part of the inverted segment have less recombination than if they are in a more extreme position. (4) Inversions affect recombination rates in the univerted regions of the chromosome. Recombination increases in the distal segment and decreases in the proximal segment. These results provide an explanation for a number of observations reported in the literature. Because inversions are ubiquitous in the evoluti...Continue Reading

Citations

Sep 4, 2008·Evolution; International Journal of Organic Evolution·Stephen W Schaeffer
Dec 1, 2008·Annual Review of Ecology, Evolution, and Systematics·Ary A Hoffmann, Loren H Rieseberg
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mineyo IwaseNaoyuki Takahata
May 9, 2021·Molecular Biology and Evolution·Claire MérotLouis Bernatchez
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rafael F GuerreroMark Kirkpatrick
Sep 27, 2007·Heredity·F Casals, A Navarro
Apr 22, 2003·Evolution; International Journal of Organic Evolution·Arcadi Navarro, Nick H Barton
Nov 15, 2012·Genetics·Nafisa-Katrin Seich Al BasatenaPaul F O'Reilly
May 15, 2013·G3 : Genes - Genomes - Genetics·Andre G WallaceStephen W Schaeffer
Jul 21, 2005·Molecular Ecology·Roger K Butlin
Nov 6, 2018·Molecular Ecology·Katharine L Korunes, Mohamed A F Noor
Sep 7, 2005·Genetics·Scotland C LemanMarcy K Uyenoyama
Sep 3, 1999·Genetics·M CáceresA Ruiz
Jan 29, 2005·Nature Genetics·Arcadi Navarro, Elodie Gazave
Apr 2, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Lyle T Wallace, Mark A Erhart
Oct 19, 2014·G3 : Genes - Genomes - Genetics·Zachary L FullerStephen W Schaeffer
Aug 9, 2019·G3 : Genes - Genomes - Genetics·R Rebecca LoveNora J Besansky
Sep 5, 2019·Proceedings. Biological Sciences·Sam Ronan FinneganAndrew Pomiankowski
Sep 7, 2019·PLoS Genetics·Sheng SunMinou Nowrousian
Jan 14, 2020·Journal of Dermatological Science·Toshifumi Nomura
Jul 24, 2002·Genetics·Josefa GonzálezAlfredo Ruiz

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