Recombination and population structure in Salmonella enterica

PLoS Genetics
Xavier DidelotPeter Donnelly

Abstract

Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme electrophoresis, recent examination of gene sequences has revealed that recombination plays an important evolutionary role. We sequenced around 10% of the core genome of 114 isolates of enterica using a resequencing microarray. Application of two different analysis methods (Structure and ClonalFrame) to our genomic data allowed us to define five clear lineages within S. enterica subspecies enterica, one of which is five times older than the other four and two thirds of the age of the whole subspecies. We show that some of these lineages display more evidence of recombination than others. We also demonstrate that some level of sexual isolation exists between the lineages, so that recombination has occurred predominantly between members of the same lineage. This pattern of recombination is compatible with expectations from the previously described ecological structuring of the enterica population as well as mechanistic barriers to recombination observed in laboratory experiments. In spite of...Continue Reading

Associated Proceedings Papers

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Related Concepts

Genetic Drift
Microarray Analysis
Neisseria meningitidis
Genome
Genes
Nucleic Acid Hybridization Procedure
Helicobacter pylori
Salmonella enterica
Recombination, Genetic
Laboratory

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