Recombination between a thermosensitive kanamycin resistance factor and a nonthermosensitive multiple-drug resistant factor.

Journal of Bacteriology
T YokotaT Akiba

Abstract

The thermosensitive kanamycin (KM) resistance factor, R(KM)(t), and a nonthermosensitive multiple-drug resistance factor, R(100), were simultaneously introduced into Escherichia coli and Salmonella typhimurium. The temperature sensitivity of both R factors remained unchanged as long as they replicated independently. Under certain conditions, however, a new thermosensitive R factor harboring resistance markers for kanamycin, streptomycin (SM), and sulfanilamide (SA) was obtained by recombination between the R(KM)(t) and R(100) factors. R factors carrying resistance markers for KM and SA, or for SM and SA, were obtained from the recombinant R(KM SA SM)(t) by spontaneous segregation. Though the R(100) factor has been known as an fi(+) (positive for F-mediated fertility inhibition of its host) type and it does not restrict any coexisting phages, the thermosensitive recombinants of R(100) with R(KM)(t) and their segregants were found to be fi(-) and to restrict the replication of all T-even phages, as does the R(KM)(t) factor. Double infection immunity was not observed between the R(KM)(t) and R(100) factors.

References

Sep 1, 1967·Journal of Bacteriology·Y TerawakiT Akiba
May 1, 1966·Nihon saikingaku zasshi. Japanese journal of bacteriology·H AbeS Kuwahara
Apr 1, 1960·Japanese Journal of Microbiology·T AKIBAT FUKUSHIMA
Dec 1, 1960·Biochemical and Biophysical Research Communications·R NAKAYAY MURATA
Nov 1, 1962·Journal of Bacteriology·Y SUGINO, Y HIROTA
Jun 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·S Benzer

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Citations

May 25, 2002·Journal of Bacteriology·Takahiro MurataTetsuya Hayashi
Dec 1, 1971·Genetical Research·T J Foster, T G Howe
Apr 1, 1970·Journal of Bacteriology·M Yoshikawa, K Sakai
Mar 1, 1975·Journal of Bacteriology·Y TerawakiR Nakaya
Mar 1, 1981·Microbiological Reviews·D H DuckworthD J McCorquodale
Sep 1, 1982·Journal of Bacteriology·B C PetersonR H Rownd
Jan 1, 1972·Journal of Bacteriology·T YokotaS Kuwahara

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