PMID: 6411613Jan 1, 1983Paper

Recombination between kappa chain genetic markers and the Lyt-3 locus

Immunogenetics
D M GibsonM Cherry

Abstract

Recombination has been detected for the first time between chromosome 6 loci controlling kappa chain expression in normal mouse serum immunoglobulin and the Lyt-3 locus. The recombination event occurred at the 26th or 27th backcross generation during the derivation of the Lyt-2a, Lyt-3a-congenic line B6.PL(85NS). The line is now homozygous for the Lyt-2a, Lyt-3a allele(s) at N30F13 and homozygous animals express the Igk-Ef1b allele derived from C57BL/6. The frequency of recombination has been estimated to be 0.30% based on the present results and previous studies in which no recombination was detected. The results rule out the hypothesis that the Lyt-3 locus itself controls the light chain phenotype observed in normal serum immunoglobulin.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H HengartnerE Müller
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Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D SwanF H Ruddle
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Jan 1, 1983·The Journal of Experimental Medicine·E Rothenberg, D Triglia

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Citations

Jan 1, 1985·Human Genetics·G BrunsL A Herzenberg
Jan 1, 1988·Immunogenetics·D Rueff-JuyP A Cazenave
Jan 1, 1984·Immunogenetics·A R Brown, P D Gottlieb
Jan 1, 1984·Immunogenetics·D M GibsonB J Mathieson
Jan 1, 1986·Immunogenetics·L A D'Hoostelaere, D M Gibson
Jan 1, 1986·Immunogenetics·I D WalkerI F McKenzie
Jan 1, 1985·Immunogenetics·B A TaylorP D Gottlieb
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·B A Richards-Smith, R W Elliott
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R W Elliott, K J Moore
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·J B GeorgeW T Garrard
Sep 1, 1984·The Journal of Experimental Medicine·N E LeeM M Davis

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