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Recombination impacts damaging and disease mutations accumulation in human populations

bioRxiv

Jun 8, 2014

Julie G HussinPhilip Awadalla

Abstract

Many decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly1, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar f...read more

Mentioned in this Paper

Sequencing
Mutation Abnormality
Species
Biologic Degeneration
Nerve Degeneration
Recombination, Genetic
Modulated
Chromosomes
Crossing Over, Genetic
Abnormal Degeneration
14
1
52
Paper Details
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Recombination impacts damaging and disease mutations accumulation in human populations

bioRxiv

Jun 8, 2014

Julie G HussinPhilip Awadalla

PMID: 990006064

DOI: 10.1101/006064

Abstract

Many decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly1, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar f...read more

Mentioned in this Paper

Sequencing
Mutation Abnormality
Species
Biologic Degeneration
Nerve Degeneration
Recombination, Genetic
Modulated
Chromosomes
Crossing Over, Genetic
Abnormal Degeneration
14
1
52
Paper Details
References
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  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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