Recombination impacts damaging and disease mutations accumulation in human populations
bioRxiv
Jun 8, 2014
Julie G HussinPhilip Awadalla
PMID: 990006064
DOI: 10.1101/006064
Abstract
Many decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly1, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar f...read more
Mentioned in this Paper
Sequencing
Mutation Abnormality
Species
Biologic Degeneration
Nerve Degeneration
Recombination, Genetic
Modulated
Chromosomes
Crossing Over, Genetic
Abnormal Degeneration
14
1
52
Paper Details
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Recombination impacts damaging and disease mutations accumulation in human populations
Abstract
Many decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly1, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar f...read more
Mentioned in this Paper
Sequencing
Mutation Abnormality
Species
Biologic Degeneration
Nerve Degeneration
Recombination, Genetic
Modulated
Chromosomes
Crossing Over, Genetic
Abnormal Degeneration
14
1
52
Related Papers
Paper Details
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