Recombination in diverse maize is stable, predictable, and associated with genetic load

Proceedings of the National Academy of Sciences of the United States of America
Eli Rodgers-MelnickEdward S Buckler

Abstract

Among the fundamental evolutionary forces, recombination arguably has the largest impact on the practical work of plant breeders. Varying over 1,000-fold across the maize genome, the local meiotic recombination rate limits the resolving power of quantitative trait mapping and the precision of favorable allele introgression. The consequences of low recombination also theoretically extend to the species-wide scale by decreasing the power of selection relative to genetic drift, and thereby hindering the purging of deleterious mutations. In this study, we used genotyping-by-sequencing (GBS) to identify 136,000 recombination breakpoints at high resolution within US and Chinese maize nested association mapping populations. We find that the pattern of cross-overs is highly predictable on the broad scale, following the distribution of gene density and CpG methylation. Several large inversions also suppress recombination in distinct regions of several families. We also identify recombination hotspots ranging in size from 1 kb to 30 kb. We find these hotspots to be historically stable and, compared with similar regions with low recombination, to have strongly differentiated patterns of DNA methylation and GC content. We also provide evid...Continue Reading

References

Sep 1, 1993·The Journal of Heredity·B Charlesworth
Apr 23, 2002·Nature Reviews. Genetics·William R Rice
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Huihua Fu, Hugo K Dooner
Mar 12, 2004·Molecular Biology and Evolution·Maud I TenaillonBrandon S Gaut
May 15, 2004·Science·Sarah P Otto, Scott L Nuismer
Feb 7, 2006·Current Opinion in Plant Biology·Edward S BucklerMichael D McMullen
Oct 4, 2006·Proceedings. Biological Sciences·Sylvain GléminDeborah Charlesworth
Jan 19, 2008·Genetics·Jianming YuEdward S Buckler
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Limei He, Hugo K Dooner
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Laurent Duret, Nicolas Galtier
Aug 8, 2009·Science·Michael D McMullenEdward S Buckler
Dec 8, 2009·Science·Michael A GoreEdward S Buckler
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Isheng J TsaiVassiliki Koufopanou
Dec 15, 2010·PLoS Computational Biology·Eugene V DavydovSerafim Batzoglou
May 17, 2011·PloS One·Robert J ElshireSharon E Mitchell
Sep 3, 2011·Evolution; International Journal of Organic Evolution·Matthew Hartfield, Sarah P Otto
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marie MirouzeJerzy Paszkowski
Mar 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cathy Melamed-Bessudo, Avraham A Levy
Apr 12, 2012·The Plant Cell·Laurana Serres-GiardiSylvain Glémin
Jun 5, 2012·Nature Genetics·Matthew B HuffordJeffrey Ross-Ibarra
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maria Colomé-TatchéFrank Johannes
Dec 28, 2012·Genome Research·Jonathan I GentR Kelly Dawe
Aug 1, 1993·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A FatmiT W Pfeiffer
Oct 1, 1991·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W D Beavis, D Grant
Nov 28, 2013·G3 : Genes - Genomes - Genetics·Sofiane Mezmouk, Jeffrey Ross-Ibarra
Mar 4, 2014·PloS One·Jeffrey C GlaubitzEdward S Buckler
Oct 4, 2014·American Journal of Human Genetics·Joseph Lachance, Sarah A Tishkoff
Sep 20, 2015·Genetics·Justin P GerkeMichael D McMullen

❮ Previous
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Citations

Dec 15, 2015·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Sen HanAlbrecht E Melchinger
Jan 24, 2016·Chromosoma·Pasquale TermolinoClara Conicella
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eli Rodgers-MelnickEdward S Buckler
Jun 16, 2016·Molecular Biology and Evolution·Thomas J Y KonoPeter L Morrell
Aug 12, 2016·Molecular Biology and Evolution·M ZhangJ A Holliday
Mar 5, 2016·Current Opinion in Plant Biology·Cathy Melamed-BessudoAvraham A Levy
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yan HeWojciech P Pawlowski
May 5, 2017·Genetics·Albrecht E MelchingerChris-Carolin Schön
Oct 28, 2019·Genetics·Thomas J Y KonoPeter L Morrell
Nov 21, 2019·G3 : Genes - Genomes - Genetics·Rami-Petteri ApuliPär K Ingvarsson
Dec 11, 2019·The Plant Journal : for Cell and Molecular Biology·Roven Rommel FuentesSander A Peters
Nov 8, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tyler V KentStephen I Wright
Apr 19, 2019·Genetics, Selection, Evolution : GSE·Martin JohnssonJohn M Hickey
Mar 26, 2016·The Plant Journal : for Cell and Molecular Biology·Yong-Xiang LiTianyu Wang
Sep 4, 2019·Nature Plants·Kyria RoesslerBrandon S Gaut
Jun 6, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Chao WeiTingdong Fu
May 30, 2020·G3 : Genes - Genomes - Genetics·Leo ZeitlerMarkus G Stetter
Jun 29, 2018·The Plant Journal : for Cell and Molecular Biology·Katherine W JordanEduard D Akhunov
May 1, 2015·The Plant Journal : for Cell and Molecular Biology·Kyuha Choi, Ian R Henderson
Jun 9, 2015·The New Phytologist·Deborah Charlesworth
Jan 1, 2016·The New Phytologist·Qingchun PanJianbing Yan
Feb 7, 2017·Nature Genetics·J Alberto Romero NavarroEdward S Buckler
Jun 15, 2016·Nature Plants·Timothy M BeissingerJeffrey Ross-Ibarra
Nov 20, 2016·The New Phytologist·Piotr A Ziolkowski, Ian R Henderson
Nov 24, 2018·Frontiers in Genetics·Andrew J Tock, Ian R Henderson
Nov 30, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A Blary, E Jenczewski
Jan 16, 2019·Nature Genetics·Chunzhi ZhangSanwen Huang
Jun 15, 2019·Plant Biotechnology Journal·Hongjun LiuXuehui Huang
Aug 25, 2018·G3 : Genes - Genomes - Genetics·Thomas J Y KonoJustin C Fay
Dec 14, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Guillaume P RamsteinEdward S Buckler
Mar 27, 2020·International Journal of Molecular Sciences·Wei RenQingchun Pan
Apr 30, 2020·The Plant Journal : for Cell and Molecular Biology·Laura MoralesPeter J Balint-Kurti
Aug 11, 2016·BMC Genomics·Jean-Marc GionJules S Freeman

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