Recombination in human mitochondrial DNA?

Genetics
C Wiuf

Abstract

The possibility of recombination in human mitochondrial DNA (mtDNA) has been hotly debated over the last few years. In this study, a general model of recombination in circular molecules is developed and applied to a recently published African sample (n = 21) of complete mtDNA sequences. It is shown that the power of correlation measures to detect recombination in circular molecules can be vanishingly small and that the data are consistent with the given model and no recombination only if the overall heterogeneity in mutation rate is <0.09.

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Citations

Jan 28, 2003·Trends in Genetics : TIG·Erika Hagelberg
Dec 13, 2006·Nature Genetics·Sarah A TishkoffPanos Deloukas
Aug 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thomas Städler, Lynda F Delph
May 5, 2005·Proceedings. Biological Sciences·Benjamin GantenbeinFrançois Balloux
May 15, 2009·PloS One·Frantz DepaulisCatherine Hänni
Sep 15, 2005·The New Phytologist·Camille M BarrDouglas R Taylor
Apr 17, 2009·Molecular Biology and Evolution·Daniel James White, Neil John Gemmell

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