Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69

Virology
Gurdeep SinghJames Chodosh

Abstract

Viruses within human adenovirus species D (HAdV-D) infect epithelia at essentially every mucosal site. Hypervariable loops 1 and 2 of the hexon capsid protein contain epitopes that together form the epsilon determinant for serum neutralization. We report our analyses comparing HAdV-D15, 29, 56, and the recently identified type 69, each with highly similar hexons and the same serum neutralization profile, but otherwise disparate genomes. Of these, only HAdV-D type 56 is associated with epidemic keratoconjunctivitis (EKC), a severe infection of ocular surface epithelium and underlying corneal stroma. In the mouse adenovirus keratitis model, all four viruses induced inflammation. However, HAdV-D56 entry into human corneal epithelial cells and fibroblasts in vitro dramatically exceeded that of the other three viruses. We conclude that the hexon epsilon determinant is not a prime contributor to corneal tropism.

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H S GinsbergG A Prince
Dec 1, 1989·Virus Research·G E BlairM E Zajdel
Jan 1, 1986·Archives of Virology·G Silverstein, W A Strohl
Nov 16, 1974·British Medical Journal·J DesmyterH Verlaeckt
Sep 1, 1969·The Journal of General Virology·E Norrby
Jan 10, 1995·Virology·P Pring-Akerblom, T Adrian
Dec 10, 1999·Journal of Virology·N ArnbergG Wadell
May 9, 2000·The Journal of Biological Chemistry·E LiG R Nemerow
Aug 11, 2000·Virology·G R Nemerow
Feb 8, 2003·Current Biology : CB·Danika L Goosney, Glen R Nemerow
Dec 16, 1955·Science·E JAWETZL HANNA
Apr 1, 1957·American Journal of Ophthalmology·Y MITSUI, E JAWETZ
Jun 1, 1958·Virology·L ROSEN
Nov 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·L ROSEN
Dec 24, 2005·Cornea·Amir Latif Butt, James Chodosh
Aug 31, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilka EngelmannAlbert Heim
Jan 26, 2007·Investigative Ophthalmology & Visual Science·Ashish V ChintakuntlawarJames Chodosh
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Feb 13, 2008·Cell·Simon N WaddingtonAndrew H Baker
Apr 4, 2008·Journal of Clinical Microbiology·Hiroaki IshikoShudo Yamazaki
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·O KalyuzhniyD M Shayakhmetov
Nov 13, 2008·Virus Research·Christopher M RobinsonJames Chodosh
May 30, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cécile HenquellHélène Peigue-Lafeuille
Aug 1, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ashish V Chintakuntlawar, James Chodosh
Apr 27, 2010·PLoS Pathogens·Ashish V ChintakuntlawarJames Chodosh
Apr 1, 2011·Journal of Virology·Donald SetoUNKNOWN Members of the Adenovirus Research Community
Aug 23, 2011·Seminars in Respiratory and Critical Care Medicine·Joseph P LynchMarcela Echavarria
Feb 4, 2012·Journal of Virology·Gurdeep SinghJames Chodosh
Apr 11, 2013·MBio·Christopher M RobinsonMorris S Jones
May 10, 2013·Scientific Reports·Christopher M RobinsonJames Chodosh

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Citations

Oct 5, 2016·Biochemistry·Mohammad A YousufJaya Rajaiya
Feb 13, 2019·Viruses·Gurdeep SinghJames Chodosh
Sep 27, 2018·Frontiers in Microbiology·Ashrafali M IsmailJaya Rajaiya
Nov 27, 2019·FEBS Letters·Ashrafali Mohamed IsmailJames Chodosh
Mar 7, 2021·Viruses·Jaya RajaiyaJames Chodosh

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